Repository logo
 
Publication

Exploring the therapeutic potential of Cu(II)-complexes with ligands derived from pyridoxal

2020-07Journal article Restricted access
Simple item page
dc.contributor.authorNunes, Patrique
dc.contributor.authorMarques, Fernanda
dc.contributor.authorCavaco, Isabel
dc.contributor.authorPessoa, Joao Costa
dc.contributor.authorCorreia, Isabel
dc.date.accessioned2021-06-24T11:35:28Z
dc.date.available2021-06-24T11:35:28Z
dc.date.issued2020-07
dc.description.abstractThree new copper(II) complexes formulated as [Cu(L)(X)], where X = H2O or Cl and H2L is a Schiff base (H2L1,2) or its reduced version ((H3LCl)-Cl-3) derived from pyridoxal, are prepared, as well as two ternary complexes [Cu(L) (phen)] also containing 1,10-phenanthroline. All compounds are characterized by the usual techniques: elemental analyses, ESI mass spectrometry, UV-Vis absorption, FTIR and EPR spectroscopies. The ligands co-ordinate the Cu(II) center forming complexes with square-planar based geometries. Their antioxidant properties are evaluated with a radical scavenging activity assay, with one of the ligand precursors showing activity higher than the positive control, ascorbic acid. The antiproliferative activity of all compounds is evaluated against two cancer cell lines: ovarian (A2780) and breast (MCF7). All complexes show moderate to excellent activity with the ternary Cu-complexes showing IC50 values between 0.7 and 9.3 mu M after 24 h of incubation, values much lower than those reported for cisplatin, the reference drug. The hydrolytic stability of the complexes and their ability to bind albumin and DNA are evaluated by spectroscopic techniques, showing that the compounds bind bovine serum albumin. The [Cu(L)(phen)] complexes show ability to target DNA via intercalation.
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.ica.2020.119558
dc.identifier.issn0020-1693
dc.identifier.urihttp://hdl.handle.net/10400.1/16449
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentro de Química Estrutural
dc.relationTherapeutic transition-metal complexes of vitamin B6 related compounds
dc.subjectPyridoxal
dc.subjectSchiff bases
dc.subjectCopper
dc.subjectCytotoxicity
dc.subjectAlbumin
dc.subject.otherChemistry
dc.titleExploring the therapeutic potential of Cu(II)-complexes with ligands derived from pyridoxal
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleTherapeutic transition-metal complexes of vitamin B6 related compounds
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F108743%2F2015/PT
oaire.citation.startPage119558
oaire.citation.titleInorganica Chimica Acta
oaire.citation.volume507
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePALMA ANTUNES CAVACO
person.givenNameISABEL MARIA
person.identifierH-9087-2012
person.identifier.ciencia-idD515-FB5E-1205
person.identifier.orcid0000-0001-8651-9054
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationb499959b-bea5-4292-bdb2-4311b0aa82de
relation.isAuthorOfPublication.latestForDiscoveryb499959b-bea5-4292-bdb2-4311b0aa82de
relation.isProjectOfPublicationdf39fd72-bd68-4aaf-8b89-25d17b8c5ebd
relation.isProjectOfPublicationc0366a4b-166c-4cbb-b888-179d5a14d120
relation.isProjectOfPublication.latestForDiscoverydf39fd72-bd68-4aaf-8b89-25d17b8c5ebd

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
16449 - main.pdf
Size:
1.17 MB
Format:
Adobe Portable Document Format
Download

Collections

FCT2-Artigos (em revistas ou actas indexadas)