Publication
Pilocytic astrocytoma
| dc.contributor.author | Lourenço, Eva PatrĂcia | |
| dc.contributor.author | Nzwalo, HipĂłlito | |
| dc.contributor.author | Sampaio, MĂĄrio Rui | |
| dc.contributor.author | Varela, Ana VerĂłnica | |
| dc.date.accessioned | 2017-04-07T15:56:56Z | |
| dc.date.available | 2017-04-07T15:56:56Z | |
| dc.date.issued | 2016-03 | |
| dc.description.abstract | Pilocytic astrocytoma (PA) is a benign tumour of childhood, often located in deep midline structures such as the brainstem and the cerebellum.1 Gross surgical resection is curative in the majority of patients.2 We report a case of recurrent PA diagnosed after an acute confusional state and rightsided spastic hemiparesis in a previously healthy 38-year-old woman. Her initial brain CT showed a left temporal mass causing obstructive hydrocephalus (ïŹgure 1AâC). Acute surgical extraction was performed (ïŹgure 1D) and the biopsy conïŹrmed the diagnosis of PA grade I (WHO). The patient remained clinically asymptomatic for 1 year, when a progressive headache emerged. At this time, the neurological examination disclosed the presence of dysarthria and right-sided hemiparesis with facial involvement. Brain MRI showed the presence of recurrent PA (ïŹgure 1E, F). The patient again underwent surgery due to the mass effect and brainstem compression caused by the tumour, and the diagnosis of PA was reconïŹrmed histologically. The patient fully recovered after the intervention. PA occurs commonly in the ïŹrst 2 decades of life.1 Information on the characteristics of PA in adulthood is scarce due to its rarity. Some studies indicate the adult prognosis to be similar to that in children, while others indicate that PA may show aggressive behaviour with tumour recurrence and death.2 Anaplastic features are associated with worse prognosis, but little is known about the value of genetic characterisation in adulthood PA.3 In conclusion, this case offers a unique description of adult onset PA in an atypical location outside the midline structures, and also provides an example of early recurrence. | |
| dc.identifier.doi | 10.1136/bcr-2015-213013 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/9567 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.relation.isbasedon | MEDLINE:27033282 | |
| dc.title | Pilocytic astrocytoma | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | BMJ case reports | |
| oaire.citation.volume | 2016 | |
| person.familyName | Nzwalo | |
| person.givenName | HipĂłlito | |
| person.identifier | 337064 | |
| person.identifier.ciencia-id | 2C1F-E4F3-2C79 | |
| person.identifier.orcid | 0000-0002-1502-3534 | |
| person.identifier.rid | AAG-3931-2020 | |
| person.identifier.scopus-author-id | 36057285600 | |
| rcaap.rights | openAccess | |
| rcaap.type | article | |
| relation.isAuthorOfPublication | 287f7d4e-5ad8-4794-b526-c61d32c00446 | |
| relation.isAuthorOfPublication.latestForDiscovery | 287f7d4e-5ad8-4794-b526-c61d32c00446 |
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