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Mismatch repair deficiency or microsatellite instability in locally advanced rectal cancer patients treated with total neoadjuvant therapy

2026-09Artigo científico Acesso restrito
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg17:Parcerias para a Implementação dos Objetivos
dc.contributor.authorBenhima, Nada
dc.contributor.authorAudisio, Alessandro
dc.contributor.authorGallio, Chiara
dc.contributor.authorRicco, Gianluca
dc.contributor.authorMeillat, Hélène
dc.contributor.authorVelenik, Vaneja
dc.contributor.authorCarmen Riesco, Maria
dc.contributor.authorSuárez Alecha, Javier
dc.contributor.authorRasschaert, Gertjan
dc.contributor.authorLópez-Bravo, David Páez
dc.contributor.authorTougeron, David
dc.contributor.authorCarvalho, Carlos
dc.contributor.authorBorelli, Beatrice
dc.contributor.authorFamiglietti, Federico
dc.contributor.authorDe la Pinta, Carolina
dc.contributor.authorManuel O’Connor, Juan
dc.contributor.authorArtaç, Mehmet
dc.contributor.authorBraam, Pètra M.
dc.contributor.authorPuccini, Alberto
dc.contributor.authorWaldhorn, Ithai
dc.contributor.authorVanden Bulcke, Alexander
dc.contributor.authorLoi, Mauro
dc.contributor.authorDe Felice, Francesca
dc.contributor.authorEid, Michal
dc.contributor.authorDeleporte, Amélie
dc.contributor.authorRossini, Chiara
dc.contributor.authorMontenegro, Paola
dc.contributor.authorFiore, Michele
dc.contributor.authorVan Den Eynde, Marc
dc.contributor.authorShamseddine, Ali
dc.contributor.authorGeboes, Karen P.
dc.contributor.authorMessina, Marco
dc.contributor.authorMulet Margalef, Núria
dc.contributor.authorHoulzé-Laroye, Constance
dc.contributor.authorKirac, Iva
dc.contributor.authorPastorino, Alessandro
dc.contributor.authorSalati, Massimiliano
dc.contributor.authorArgalácsová, Soňa
dc.contributor.authorMorano, Federica
dc.contributor.authorCapdevila, Jaume
dc.contributor.authorGarajovà, Ingrid
dc.contributor.authorAntoun, Claire
dc.contributor.authorPinto, Cidália Maria Sousa
dc.contributor.authorLutz, Manfred P.
dc.contributor.authorAdams, Richard A.
dc.contributor.authorChau, Amélie
dc.contributor.authorSiebenhuener, Alexander
dc.contributor.authorDermine, Alexandre
dc.contributor.authorGhidini, Michele
dc.contributor.authorDulskas, Audrius
dc.contributor.authorPapamichael, Demetris
dc.contributor.authorJaved, Muhammad Ahsan
dc.contributor.authorRuiz-Garcia, Erika
dc.contributor.authorTomášek, Jiří
dc.contributor.authorPetrillo, Angelica
dc.contributor.authorBaratelli, Chiara
dc.contributor.authorVandamme, Timon
dc.contributor.authorSpolverato, Gaya
dc.contributor.authorBock, Felix
dc.contributor.authorDiaz, Marie
dc.contributor.authorCampana, Luca Giovanni
dc.contributor.authorSur, Daniel
dc.contributor.authorKarampeazis, Athanasios
dc.contributor.authorPatsko, Veronika
dc.contributor.authorPuleo, Francesco
dc.contributor.authorBounedjar, Adda
dc.contributor.authorFiorica, Francesco
dc.contributor.authorGilliaux, Quentin
dc.contributor.authorBernardini, Ilaria
dc.contributor.authorDe Stefano, Alfonso
dc.contributor.authorGuren, Marianne Grønlie
dc.contributor.authorJakubauskas, Matas
dc.contributor.authorSert, Fatma
dc.contributor.authorGomez Galdon, Maria
dc.contributor.authorVeron Sanchez, Ana
dc.contributor.authorVierasu, Ortansa-Irina
dc.contributor.authorAssaf, Irene
dc.contributor.authorMoretti, Luigi
dc.contributor.authorMartinive, Philippe
dc.contributor.authorLiberale, Gabriel
dc.contributor.authorVan Laethem, Jean-Luc
dc.contributor.authorSclafani, Francesco
dc.date.accessioned2026-08-27T13:28:56Z
dc.date.available2026-08-27T13:28:56Z
dc.date.issued2026-09
dc.description.abstractBackground: Data on the prognostic value of dMMR/MSI-H in locally advancer rectal cancer (LARC) are inconsistent and mostly from patients treated with conventional neoadjuvant therapy. We sought to evaluate oncological outcomes by mismatch repair/microsatellite (MMR/MS) status in LARC patients treated with total neoadjuvant therapy (TNT). Methods: Patients from the International Real-World Study of TNT in Rectal Cancer tested for dMMR/MSI-H by immunohistochemistry and/or molecular testing were included. Pathological complete response (pCR), complete response (CR, pCR + clinical complete response), event-free survival (EFS) and overall survival (OS) were assessed by MMR/MS status in the overall and matched populations. For the latter, variable-ratio matching according to nine variables (age, year of diagnosis, tumour location, staging modality, cT stage, cN stage, presence of lateropelvic lymphadenopathy, distance from the mesorectal fascia, TNT regimen) was applied. Results: Of 1911 patients, 1320 (69.1%) (09/2012-09/2025) had information on the MMR/MS status, 46 (3.5%) having dMMR/MSI-H tumours. No outcome differences were found by MMR/MS status in the overall population. In the matched population (n = 372), pCR was 14.2% among patients with pMMR/MSS tumours versus 12.5% among those with dMMR/MSI-H tumours (adjusted OR 1.07, 95%CI 0.39-2.91, p = 0.899), while CR was 18.9% and 16.7%, respectively (adjusted OR 0.95, 95%CI 0.35-2.58, p = 0.917). 3-year EFS and 5-year OS were 65.8% and 79.2%, and 67.6% and 93.5% in patients with pMMR/MSS and in those with dMMR/MSI-H tumours, respectively (adjusted HR EFS 1.30, 95%CI 0.57-2.89, p = 0.527; adjusted HR OS 2.52, 95%CI 0.67-9.42, p = 0.171). Conclusions: In this study, the dMMR/MSI-H phenotype did not hold prognostic value in LARC patients treated with TNT.eng
dc.identifier.doi10.1016/j.ejca.2026.116911
dc.identifier.issn0959-8049
dc.identifier.urihttp://hdl.handle.net/10400.1/29346
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier BV
dc.relation.hasversionhttps://www.ejcancer.com/article/S0959-8049(26)00692-1/fulltext
dc.relation.ispartofEuropean Journal of Cancer
dc.rights.uriN/A
dc.subjectMicrosatellite instability-high (MSI-H)
dc.subjectMicrosatellite stability (MSS)
dc.subjectMismatch repair deficiency (dMMR)
dc.subjectMismatch repair proficiency (pMMR)
dc.subjectRectal cancer
dc.subjectTotal neoadjuvant therapy (TNT)
dc.titleMismatch repair deficiency or microsatellite instability in locally advanced rectal cancer patients treated with total neoadjuvant therapyeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage116911
oaire.citation.titleEuropean Journal of Cancer
oaire.citation.volume245
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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