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Hybrid chemical-biogenic synthesis of silver nanoparticles with antibacterial efficacy using salicornia and sarcocornia hydroethanolic extracts

2026-08-23Artigo científico Acesso restrito
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorHarboub, Nesrine
dc.contributor.authorAmaral, Mariana Neves
dc.contributor.authorMighrim, Hedi
dc.contributor.authorMaria, Rui Miguel
dc.contributor.authorElias, Rita
dc.contributor.authorPerdigão, João
dc.contributor.authorNunes, Daniela
dc.contributor.authorFortunato, Elvira
dc.contributor.authorMartins, Rodrigo
dc.contributor.authorCustódio, Luísa
dc.contributor.authorReis, Catarina Pinto
dc.contributor.authorAkrout, Ahmed
dc.contributor.authorAbdellaoui, Raoudha
dc.date.accessioned2026-09-22T14:27:43Z
dc.date.available2026-09-22T14:27:43Z
dc.date.issued2026-08-23
dc.description.abstractThis study investigates the use of a hybrid approach combining various ratios of sodium borohydride (NaBH4) with hydroethanolic extracts of Salicornia emerici, Sarcocornia fruticosa, and Sarcocornia alpini as reducing agents for AgNPs synthesis. The resulting nanoparticles were confirmed by the presence of a characteristic absorption peak around 400nm using UV-visible spectroscopy, observed for Sarcocornia-mediated AgNPs at a 1:5 (v/v) extract-to-NaBH4 ratio and at a 1:2 (v/v) ratio for AgNPs synthesized from S. emerici (SE-AgNPs). Furthermore, their size, dispersity and morphology were characterized using dynamic light scattering (DLS) and scanning electron microscopy (SEM), respectively. The nanoparticles displayed variable sizes with broad polydispersity, reflecting heterogeneous nucleation associated with plant-derived metabolites, and predominantly exhibited a cubic shape. Their antibacterial activity against different bacterial strains was evaluated using the broth microdilution method. All formulations inhibited bacterial growth, showing size-independent efficacy. The inhibition of multidrug-resistant bacteria Enterococcus faecalis was particularly noteworthy, with the strongest efficacy observed in SE-AgNPs at a concentration of 21.9µg/mL. Taken together, the findings suggest that hybrid synthesis can generate bioactive AgNPs while partially reducing dependence on strong chemical reductants. Future work should focus on improving nanoparticle size control, cytotoxicity assessment, and elucidating the mechanistic pathways underlying their bioactivity.eng
dc.description.sponsorshipUIDP/00645/2020; SFRH/BD/05377/2021
dc.identifier.doi10.1080/10826068.2026.2716087
dc.identifier.eissn1532-2297
dc.identifier.issn1082-6068
dc.identifier.urihttp://hdl.handle.net/10400.1/29497
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis
dc.relationInstitute of <biophysics and Biomedical Engineering
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relation.ispartofPreparative Biochemistry &amp; Biotechnology
dc.rights.uriN/A
dc.subjectAntibacterial activity
dc.subjectHybrid synthesis
dc.subjectSilver nanoparticles
dc.subjectSarcocornia
dc.subjectSalicornia
dc.titleHybrid chemical-biogenic synthesis of silver nanoparticles with antibacterial efficacy using salicornia and sarcocornia hydroethanolic extractseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00645/2020
oaire.awardNumberUIDB/04138/2020
oaire.awardNumberUIDP/04138/2020
oaire.awardTitleInstitute of <biophysics and Biomedical Engineering
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00645%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT
oaire.citation.titlePreparative Biochemistry & Biotechnology
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCustódio
person.givenNameLuísa
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscoveryf9cfed0f-6b67-413e-988c-ac7397183471
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