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Exploration of UHPLC-ESI-QTOF-MS profiles and the neuroprotective, antidiabetic, antioxidant and cytotoxic effects of extracts from achillea maritima (L.) Ehrend. & Y.P.Guo (Asteraceae) collected in Türkiye

2025-02-13Journal article Open access
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dc.contributor.authorAhmed, Shakeel
dc.contributor.authorZengin, Gokhan
dc.contributor.authorFernández-Ochoa, Álvaro
dc.contributor.authorCádiz-Gurrea, Maria de la Luz
dc.contributor.authorLeyva-Jiménez, Francisco Javier
dc.contributor.authorElkiran, Omer
dc.contributor.authorCakilcioglu, Ugur
dc.contributor.authorAkgul, Bengusu H.
dc.contributor.authorGuerreiro Pereira, Catarina Alexandra
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2025-04-04T09:34:58Z
dc.date.available2025-04-04T09:34:58Z
dc.date.issued2025-02-13
dc.description.abstractThe current study investigated the chemical composition, antioxidant activity, enzyme inhibition, and cytotoxic activities of extracts from Achillea maritima, a wild medicinal plant used for various therapeutic purposes. The antioxidant activities were assayed through different assays like DPPH, ABTS, CUPRAC, FRAP, and phosphomolybdenum, whereas in enzyme inhibition studies, cholinesterase, tyrosinase, alpha-amylase, and alpha-glucosidase were assayed. Cytotoxicity studies are conducted on S17, RAW, and HepG2 to assess its selectivity and effectiveness. Chemical profiling by UHPLC-ESI-QTOF-MS revealed multiple bioactive compounds in the extracts. Polar solvents (ethanol, ethanol/water, and water) resulted in high concentrations of phenolic acids as well as chlorogenic and caffeoylquinic acids, as well as flavonoids like vicenin and apigenin. On the other, the nonpolar (hexane extract) was rich in octadecatrienoic acid hydroperoxy and hydroxyoctadecatrienic acid. Among these, the water extract contained the highest phenolic content of 32.26 mg GAE/g, while the ethyl acetate extract was the richest in flavonoids, with 7.83 mg RE/g. In the antioxidant studies, the water and ethanol/water extracts consistently display the most potent activities, thus indicating their significant free radical scavenging and metal chelation abilities. The studies on enzyme inhibitions showed remarkable BChE inhibitory activities of the ethanol extract in 12.50 mg GALAE/g, thus showing potential in managing disease conditions related to cholinesterase. Tyrosinase inhibition was significant by the ethanol extract, presenting 55.59 mg KAE/g. The ethyl acetate extract exhibited the most potent inhibitory activity against alpha-amylase with 0.66 mmol ACAE/g, while ethanol extract showed significant inhibition of alpha-glucosidase with 4.35 ACAE/g. Cytotoxicity results showed that the water extract was most effective against the HepG2 cancer cell line by reducing cell viability to 38.4% at high doses while preserving low toxicity against normal cells, as observed by high viability percentages in S17 and RAW cell lines. These results highlight the usefulness of A. maritima extracts in nutraceutical, pharmaceutical, and cosmeceutical applications.eng
dc.identifier.doi10.1007/s11130-025-01314-x
dc.identifier.eissn1573-9104
dc.identifier.issn0921-9668
dc.identifier.urihttp://hdl.handle.net/10400.1/26975
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relation.ispartofPlant Foods for Human Nutrition
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectA. maritima
dc.subjectEnzyme inhibition
dc.subjectCytotoxicity
dc.subjectAntioxidant
dc.subjectChemical profiling
dc.titleExploration of UHPLC-ESI-QTOF-MS profiles and the neuroprotective, antidiabetic, antioxidant and cytotoxic effects of extracts from achillea maritima (L.) Ehrend. & Y.P.Guo (Asteraceae) collected in Türkiyeeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPage66
oaire.citation.titlePlant Foods for Human Nutrition
oaire.citation.volume80
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
relation.isAuthorOfPublication164572fc-85ed-4377-afd0-7ab4c8fdc79f
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery164572fc-85ed-4377-afd0-7ab4c8fdc79f

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