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Warfarin effects in the skeletal development of zebrafish (Danio rerio)

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dc.contributor.authorPeres dos Santos, R.
dc.contributor.authorBensimon-Brito, A.
dc.contributor.authorGavaia, Paulo J.
dc.contributor.authorCancela, Leonor
dc.date.accessioned2014-06-18T12:13:04Z
dc.date.available2014-06-18T12:13:04Z
dc.date.issued2009
dc.description.abstractVitamin K-dependent gamma carboxylation (VKGC) is crucial for posttranslational modification of glutamate residues to form α-carboxy glutamic acid (Gla) in the presence of reduced vitamin K, molecular oxygen, and carbon dioxide (1). This modification has important implications, mainly physiological, like homeostasis, signal transduction and bone calcification. This mechanism ensures complete carboxylation of coagulation factors, and proteins like bone Gla protein (BGP) and matrix Gla protein (MGP), being essential for their biological activity. Warfarin is a known anticoagulant that inhibits the action of VKGC (2), inhibiting consequently the activity of the referred proteins.por
dc.identifier.citationPeres dos Santos R., Bensimon-Brito A., Gavaia P., Cancela M.L. 2009. Warfarin effects in the skeletal development of zebrafish (Danio rerio). Interdisciplinary Approaches in Fish Skeletal Biology, April 27 – 29 Tavira, Portugal.por
dc.identifier.urihttp://hdl.handle.net/10400.1/4382
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherCentre of Marine Sciencespor
dc.relationINSIGHTS INTO MOLECULAR AND CELULLAR EVENTS INVOLVED IN HUMAN PATHOLOGICAL FUSION OF VERTEBRAL JOINTS THROUGH THE USE OF ZEBRAFISH AS MODEL ORGANISM
dc.titleWarfarin effects in the skeletal development of zebrafish (Danio rerio)por
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleINSIGHTS INTO MOLECULAR AND CELULLAR EVENTS INVOLVED IN HUMAN PATHOLOGICAL FUSION OF VERTEBRAL JOINTS THROUGH THE USE OF ZEBRAFISH AS MODEL ORGANISM
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBD%2F40573%2F2007/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FMAR%2F60883%2F2004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PIHM%2FGC%2F0006%2F2008/PT
oaire.citation.conferencePlaceTavirapor
oaire.citation.endPage59por
oaire.citation.startPage59por
oaire.citation.titleInterdisciplinary Approaches in Fish Skeletal Biologypor
oaire.fundingStreamPIDDAC
oaire.fundingStreamPOCI
oaire.fundingStream3599-PPCDT
person.familyNameBensimon-Brito
person.familyNameGavaia
person.familyNameCancela
person.givenNameAnabela
person.givenNamePaulo
person.givenNameM. Leonor
person.identifier1460592
person.identifier.ciencia-id8419-63A7-D0E5
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0003-1663-2232
person.identifier.orcid0000-0002-9582-1957
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridN-7291-2014
person.identifier.ridA-6470-2011
person.identifier.scopus-author-id36154529200
person.identifier.scopus-author-id6507104377
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typeconferenceObjectpor
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