Warfarin effects in the skeletal development of zebrafish (Danio rerio)

Peres dos Santos, R.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor

http://hdl.handle.net/10400.1/4382

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Abstract(s)

Vitamin K-dependent gamma carboxylation (VKGC) is crucial for posttranslational modification of glutamate residues to form α-carboxy glutamic acid (Gla) in the presence of reduced vitamin K, molecular oxygen, and carbon dioxide (1). This modification has important implications, mainly physiological, like homeostasis, signal transduction and bone calcification. This mechanism ensures complete carboxylation of coagulation factors, and proteins like bone Gla protein (BGP) and matrix Gla protein (MGP), being essential for their biological activity. Warfarin is a known anticoagulant that inhibits the action of VKGC (2), inhibiting consequently the activity of the referred proteins.

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http://hdl.handle.net/10400.1/4382

Citation

Peres dos Santos R., Bensimon-Brito A., Gavaia P., Cancela M.L. 2009. Warfarin effects in the skeletal development of zebrafish (Danio rerio). Interdisciplinary Approaches in Fish Skeletal Biology, April 27 – 29 Tavira, Portugal.