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Metamorphosis-associated immune system maturation in Senegalese sole

2025-06Journal article Open access
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dc.contributor.authorSilva, Sandra
dc.contributor.authorCorreia, Teresa
dc.contributor.authorManchado, Manuel
dc.contributor.authorPower, Deborah Mary
dc.date.accessioned2025-07-17T10:41:01Z
dc.date.available2025-07-17T10:41:01Z
dc.date.issued2025-06
dc.description.abstractThe thyroid hormones (THs) are proposed as putative regulators of immune system maturation in developing teleost fish. To gain insight into this process the Senegalese sole (Solea senegalensis) that has a well-characterized TH-driven metamorphosis was used. Differential gene expression analysis was performed across developmental stages (n = 3 per stage): pre-metamorphosis, onset of metamorphosis, metamorphosis, early climax, climax, and post-metamorphic juveniles. Metamorphosis is a massive gene-oriented developmental process, involving the differential expression of 8145 genes. Clustering analysis was used to identify immune-related genes with similar expression patterns to hypothalamus-pituitary-thyroid (HPT) axis-related genes. TH-regulated candidate immune genes were identified (133) and analysis of their promoter region revealed 84 contained putative TH receptor (TR) binding sites (TREs). Two consensus TRE sequences were identified in the candidate genes, 5 '-ntgnGntCacan (exclusive to TR alpha), and 5 '-nnntGgtCannn (common to both TRs). TR alpha-exclusive TREs were less common than those that bound interchangeably TR alpha and TR beta. In the promoter region, TR alpha-exclusive TREs were always accompanied by the pan-TRE consensus sequence, never occurring independently.eng
dc.description.sponsorshipPT ALG-01-0145-FEDER-022121 and BIODATA.PT ALG-01-0145-FEDER-022231; SFRH/BD/08486/2020
dc.identifier.doi10.1016/j.ygcen.2025.114755
dc.identifier.issn0016-6480
dc.identifier.urihttp://hdl.handle.net/10400.1/27432
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofGeneral and Comparative Endocrinology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectFlatfish metamorphosis
dc.subjectImmune development
dc.subjectTeleost
dc.subjectThyroid hormones
dc.subjectThyroid-response elements
dc.subjectTranscriptomics
dc.titleMetamorphosis-associated immune system maturation in Senegalese soleeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.issue114755
oaire.citation.startPage114755
oaire.citation.titleGeneral and Comparative Endocrinology
oaire.citation.volume369
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSilva
person.familyNameCorreia
person.familyNamePower
person.givenNameSandra
person.givenNameTeresa
person.givenNameDeborah Mary
person.identifier.ciencia-id9A10-9756-78D0
person.identifier.ciencia-idF01E-082A-5B36
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-6692-3620
person.identifier.orcid0000-0002-1606-9550
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id23392190500
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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