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Fish models of induced osteoporosis

2021-06Journal article Open access
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dc.contributor.authorRosa, Joana
dc.contributor.authorLaizé, Vincent
dc.contributor.authorGavaia, Paulo
dc.contributor.authorCancela, M. Leonor
dc.date.accessioned2021-07-08T13:19:34Z
dc.date.available2021-07-08T13:19:34Z
dc.date.issued2021-06
dc.description.abstractOsteopenia and osteoporosis are bone disorders characterized by reduced bone mineral density (BMD), altered bone microarchitecture and increased bone fragility. Because of global aging, their incidence is rapidly increasing worldwide and novel treatments that would be more efficient at preventing disease progression and at reducing the risk of bone fractures are needed. Preclinical studies are today a major bottleneck to the collection of new data and the discovery of new drugs, since they are commonly based on rodent in vivo systems that are time consuming and expensive, or in vitro systems that do not exactly recapitulate the complexity of low BMD disorders. In this regard, teleost fish, in particular zebrafish and medaka, have recently emerged as suitable alternatives to study bone formation and mineralization and to model human bone disorders. In addition to the many technical advantages that allow faster and larger studies, the availability of several fish models that efficiently mimic human osteopenia and osteoporosis phenotypes has stimulated the interest of the academia and industry toward a better understanding of the mechanisms of pathogenesis but also toward the discovery of new bone anabolic or antiresorptive compounds. This mini review recapitulates the in vivo teleost fish systems available to study low BMD disorders and highlights their applications and the recent advances in the field.pt_PT
dc.description.sponsorshipUIDB/04326/2020, EAPA_151/2016/BLUEHUMANpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fcell.2021.672424pt_PT
dc.identifier.issn2296-634X
dc.identifier.urihttp://hdl.handle.net/10400.1/16752
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Media SApt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTeleostspt_PT
dc.subjectModelo de peixept_PT
dc.subjectOsteoporose induzidapt_PT
dc.subjectPeneiramentopt_PT
dc.subjectcompostos anabólicos ósseospt_PT
dc.titleFish models of induced osteoporosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage672424pt_PT
oaire.citation.titleFrontiers in Cell and Developmental Biologypt_PT
oaire.citation.volume9pt_PT
person.familyNameRosa
person.familyNameLaizé
person.familyNameGavaia
person.familyNameCancela
person.givenNameJoana
person.givenNameVincent
person.givenNamePaulo
person.givenNameM. Leonor
person.identifier.ciencia-id0B18-8AEC-875C
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0001-7947-2681
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0002-9582-1957
person.identifier.orcid0000-0003-3114-6662
person.identifier.ridB-4463-2008
person.identifier.ridA-6470-2011
person.identifier.scopus-author-id36505067900
person.identifier.scopus-author-id6602982778
person.identifier.scopus-author-id6507104377
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationb9bbfe32-3dfe-4131-ad14-a4394008447f
relation.isAuthorOfPublication.latestForDiscovery181f1017-5086-40dc-9edc-a289aaa2d263

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