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Predictive value for increased red blood cell distribution width in unprovoked acute venous thromboembolism at the emergency department

2023Journal article Open access
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dc.contributor.authorFebra, Cláudia
dc.contributor.authorSpinu, Verónica
dc.contributor.authorFerreira, Filipa
dc.contributor.authorGil, Victor
dc.contributor.authorMaio, Rui
dc.contributor.authorPenque, Deborah
dc.contributor.authorMacedo, Ana
dc.date.accessioned2023-11-06T10:36:26Z
dc.date.available2023-11-06T10:36:26Z
dc.date.issued2023
dc.description.abstractAcute venous thromboembolism (VTE) is a common worldwide disease admitted to emergency departments (ED), usually presenting as pulmonary embolism or lower limb deep vein thrombosis (DVT). Due to the lack of typical clinical and biomarker diagnostic features of unprovoked VTE, early identification is challenging and has direct consequences on correct treatment delay. Longitudinal, prospective, observational study. Patients admitted to ED with a suspicion of unprovoked acute VTE between October 2020 and January 2021 were included. Clinical and laboratorial variables were compared between VTE positive and negative diagnoses. Red cell distribution width (RDW) cut point was determinate through a receiver operating characteristic analysis. RDW accuracy, sensitivity, and specificity were calculated. Fifty-eight patients were analyzed. And 82.8% of suspected patients with VTE were diagnosed with an acute thrombotic event confirmed by imaging examination. In patients with VTE, RDW at admission in ED was higher than with other diagnosis, respectively, 14.3% (13.2-15.1) and 13.5% (13.0-13.8). Platelet count was the only additional characteristic that revealed difference between the 2 groups (264x109/L for VTE and 209x109/L for non-VTE). Logistic regression models showed good discriminatory values for RDW & GE;14%, with an area under the curve (AUC) = 0.685 (95% confidence interval, 0.535-0.834). These findings were more pronounced in isolated DVT, with a sensitivity of 76.9%, specificity 100%, and accuracy 85.7%. Our study demonstrated a significant association between an early high RDW and the diagnosis of acute unprovoked DVT. RDW & GE; 14% has an independent predictor of unprovoked VTE in adult patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1177/10760296231193397pt_PT
dc.identifier.eissn1938-2723
dc.identifier.urihttp://hdl.handle.net/10400.1/20124
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSagept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectRed cell distribution widthpt_PT
dc.subjectErythrocytes indicespt_PT
dc.subjectVenous thromboembolismpt_PT
dc.titlePredictive value for increased red blood cell distribution width in unprovoked acute venous thromboembolism at the emergency departmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage7pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleClinical and Applied Thrombosis/Hemostasispt_PT
oaire.citation.volume29pt_PT
person.familyNameMacedo
person.givenNameAna
person.identifier.ciencia-id8414-F029-8182
person.identifier.orcid0000-0002-6978-8989
person.identifier.ridL-9912-2018
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8e798bcb-5052-47b0-a050-32f40328cc1a
relation.isAuthorOfPublication.latestForDiscovery8e798bcb-5052-47b0-a050-32f40328cc1a

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