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Neuropeptides and receptors in the cephalochordate: a crucial model for understanding the origin and evolution of vertebrate neuropeptide systems

2024-10Artigo científico Acesso restrito
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dc.contributor.authorSu, Liuru
dc.contributor.authorLi, Guang
dc.contributor.authorChow, Billy K. C.
dc.contributor.authorCardoso, João
dc.date.accessioned2024-11-26T14:28:42Z
dc.date.available2024-11-26T14:28:42Z
dc.date.issued2024-10
dc.description.abstractGenomes and transcriptomes from diverse organisms are providing a wealth of data to explore the evolution and origin of neuropeptides and their receptors in metazoans. While most neuropeptide-receptor systems have been extensively studied in vertebrates, there is still a considerable lack of understanding regarding their functions in invertebrates, an extraordinarily diverse group that account for the majority of animal species on Earth. Cephalochordates, commonly known as amphioxus or lancelets, serve as the evolutionary proxy of the chordate ancestor. Their key evolutionary position, bridging the invertebrate to vertebrate transition, has been explored to uncover the origin, evolution, and function of vertebrate neuropeptide systems. Amphioxus genomes exhibit a high degree of sequence and structural conservation with vertebrates, and sequence and functional homologues of several vertebrate neuropeptide families are present in cephalochordates. This review aims to provide a comprehensively overview of the recent findings on neuropeptides and their receptors in cephalochordates, highlighting their significance as a model for understanding the complex evolution of neuropeptide signaling in vertebrates.eng
dc.description.sponsorshipN_HKU742/20; 32061160471
dc.identifier.doi10.1016/j.mce.2024.112324
dc.identifier.issn0303-7207
dc.identifier.urihttp://hdl.handle.net/10400.1/26346
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofMolecular and Cellular Endocrinology
dc.rights.uriN/A
dc.subjectNeuropeptide
dc.subjectAmphioxus
dc.subjectEvolution
dc.subjectReceptors
dc.subjectNeuroendocrine system
dc.titleNeuropeptides and receptors in the cephalochordate: a crucial model for understanding the origin and evolution of vertebrate neuropeptide systemseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.startPage112324
oaire.citation.titleMolecular and Cellular Endocrinology
oaire.citation.volume592
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCardoso
person.givenNameJoão
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.orcid0000-0001-7890-0170
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublication.latestForDiscovery1b670c84-15e3-4776-8871-50f9eb0eed0d
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