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Comparative metabolomic and bioactivity profiling of wild and greenhouse–Transplanted Plantago coronopus L

2025-09Journal article Open access
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dc.contributor.authorTrentin, Riccardo
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorSantos, Alexia dos
dc.contributor.authorFernandes, Eliana
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2025-10-02T09:57:40Z
dc.date.available2025-10-02T09:57:40Z
dc.date.issued2025-09
dc.description.abstractThis study investigates the influence of growing conditions on the metabolomic composition and associated bioactivities of Plantago coronopus L. Methanol extracts were prepared from freeze-dried biomass of both wild and greenhouse-transplanted plants and evaluated for in vitro antioxidant capacity and inhibitory effects on enzymes relevant to Alzheimer's disease (acetylcholinesterase, butyrylcholinesterase), type 2 diabetes (alpha-glucosidase, alpha-amylase), and obesity-related disorders (lipase). An untargeted metabolomic analysis was performed using mass spectral library matching and in silico annotation tools to characterise the chemical composition of the extracts. Extracts from wild specimens exhibited stronger antioxidant activity and cholinesterase inhibition, coinciding with higher levels of total phenolics, flavonoids, and carbohydrates. These differences were associated with increased levels of bioactive metabolites, including caffeic acid derivatives, terpenoids, and lipid-like compounds, possibly linked to environmental stress responses. Despite lower bioactivity, greenhouse-grown plants still produced valuable compounds such as acteoside, echinacoside, and plantamajoside. These findings highlight the potential of P. coronopus as a source of bioactive metabolites and suggest that manipulating environmental conditions in controlled cultivation could enhance phytochemical yields.eng
dc.description.sponsorshipEMBRC.PT ALG-01–0145-FEDER02212; CEECIND/00425/2017
dc.identifier.doi10.1016/j.sajb.2025.07.038
dc.identifier.issn0254-6299
dc.identifier.urihttp://hdl.handle.net/10400.1/27776
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationInstitute for Bioengineering and Biosciences
dc.relationCentre for Marine and Environmental Research
dc.relationAlgarve Centre for Marine Sciences
dc.relationXTREMEVEGGIES - SUSTAINABLE HALOPHYTES CULTIVATION TARGETING MULTIPLE COMMERCIAL PURPOSES
dc.relation.ispartofSouth African Journal of Botany
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPhenolic compounds
dc.subjectEnvironmental stress
dc.subjectSecondary metabolism
dc.subjectBuck’s-horn plantain
dc.titleComparative metabolomic and bioactivity profiling of wild and greenhouse–Transplanted Plantago coronopus Leng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleXTREMEVEGGIES - SUSTAINABLE HALOPHYTES CULTIVATION TARGETING MULTIPLE COMMERCIAL PURPOSES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151301%2F2021/PT
oaire.citation.endPage1274
oaire.citation.startPage1265
oaire.citation.titleSouth African Journal of Botany: An International Interdisciplinary Journal for Plant Sciences
oaire.citation.volume184
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameTrentin
person.familyNameRodrigues
person.familyNameFernandes
person.familyNameCustódio
person.givenNameRiccardo
person.givenNameMaria João
person.givenNameEliana
person.givenNameLuísa
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0002-2886-3364
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4083-8353
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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