Marine 5-thiohistidines as protective molecules from skin damage

Brancaccio, M.; Milito, A.; Viegas, C. V.; Simes, DC; Castellano, I.

http://hdl.handle.net/10400.1/12828

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Introduction Marine environment is a great source of bioactive molecules, whose biological properties and applications are often used especially to prevent skin diseases and aging caused by UVAexposure. Ovothiols are methyl5thiohistidines from marine invertebrates, bacteria, and microalgae, which protect cells from environmental stressors. Recently, we have shown that, ovothiol, isolated from sea urchin eggs, exerts antiinflammatory and antioxidant activities on human endothelial cells, and exhibits antifibrotic effect in an in vivo model of liver fibrosis.