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m6A RNA Methylation in marine plants: first insights and relevance for biological rhythms

2020Journal article Open access
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dc.contributor.authorRuocco, Miriam
dc.contributor.authorAmbrosino, Luca
dc.contributor.authorJahnke, Marlene
dc.contributor.authorChiusano, Maria
dc.contributor.authorBarrote, Isabel
dc.contributor.authorProcaccini, Gabriele
dc.contributor.authorSilva, João
dc.contributor.authorDattolo, Emanuela
dc.date.accessioned2020-11-25T13:42:25Z
dc.date.available2020-11-25T13:42:25Z
dc.date.issued2020
dc.description.abstractCircadian regulations are essential for enabling organisms to synchronize physiology with environmental light-dark cycles. Post-transcriptional RNA modifications still represent an understudied level of gene expression regulation in plants, although they could play crucial roles in environmental adaptation. N6-methyl-adenosine (m6A) is the most prevalent mRNA modification, established by "writer" and "eraser" proteins. It influences the clockwork in several taxa, but only few studies have been conducted in plants and none in marine plants. Here, we provided a first inventory of m6A-related genes in seagrasses and investigated daily changes in the global RNA methylation and transcript levels of writers and erasers in Cymodocea nodosa and Zostera marina. Both species showed methylation peaks during the dark period under the same photoperiod, despite exhibiting asynchronous changes in the m6A profile and related gene expression during a 24-h cycle. At contrasting latitudes, Z. marina populations displayed overlapping daily patterns of the m6A level and related gene expression. The observed rhythms are characteristic for each species and similar in populations of the same species with different photoperiods, suggesting the existence of an endogenous circadian control. Globally, our results indicate that m6A RNA methylation could widely contribute to circadian regulation in seagrasses, potentially affecting the photo-biological behaviour of these plants.pt_PT
dc.description.sponsorshipFCT: UIDB/04326/2020pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ijms21207508pt_PT
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10400.1/14845
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMarine plantspt_PT
dc.subjectm6A-methylationpt_PT
dc.subjectEpitranscriptomept_PT
dc.subjectRNA methyltransferasespt_PT
dc.subjectCircadian clockpt_PT
dc.titlem6A RNA Methylation in marine plants: first insights and relevance for biological rhythmspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue20pt_PT
oaire.citation.startPage7508pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume21pt_PT
person.familyNameBarrote
person.familyNameSilva
person.givenNameIsabel
person.givenNameJoão
person.identifier82814
person.identifier.ciencia-id801C-0AE4-B5CA
person.identifier.ciencia-id8216-527E-1BD4
person.identifier.orcid0000-0002-0922-0259
person.identifier.orcid0000-0002-7211-1661
person.identifier.ridJ-7874-2013
person.identifier.scopus-author-id8659654200
person.identifier.scopus-author-id7403023547
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8027b4d2-ee8d-4432-be75-7a2342a905a8
relation.isAuthorOfPublication61040b53-b17a-40f6-b42e-f5476a7a6ddb
relation.isAuthorOfPublication.latestForDiscovery8027b4d2-ee8d-4432-be75-7a2342a905a8

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