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Ultra-low noise PEDOT:PSS electrodes on bacterial cellulose: A sensor to access bioelectrical signals in non-electrogenic cells

2020-10Journal article Restricted access
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dc.contributor.authorInacio, Pedro M. C.
dc.contributor.authorMedeiros, Maria C. R.
dc.contributor.authorCarvalho, Tiago
dc.contributor.authorFélix, Rute
dc.contributor.authorMestre, Ana
dc.contributor.authorHubbard, Peter
dc.contributor.authorFerreira, Quirina
dc.contributor.authorMorgado, Jorge
dc.contributor.authorCharas, Ana
dc.contributor.authorFreire, Carmen S. R.
dc.contributor.authorBiscarini, Fabio
dc.contributor.authorPower, Deborah
dc.contributor.authorGomes, Henrique L.
dc.date.accessioned2021-06-24T11:35:13Z
dc.date.available2021-06-24T11:35:13Z
dc.date.issued2020-10
dc.description.abstractThis study is focused on the particular advantages of organic-based devices to measure cells that do not generate action potentials, also known as non-electrogenic cells. While there is a vast literature about the application of organic conductors to measure neurons, cardiomyocytes and brain tissues, electrical measurements of non-electrogenic cells are rare. This is because non-electrogenic cells generate weak signals with frequencies below 1 Hz. Designing low noise devices in a millihertz frequency range is extremely challenging due to the intrinsic thermal and 1/f type noise generated by the sensing electrode. Here, we demonstrate that the coating of cellulose nanofibers with conducting PEDOT:PSS ink allows the fabrication of a nanostructured surface that establishes a low electrical double-layer resistance with liquid solutions. The low interfacial resistance combined with the large effective sensing area of PEDOT:PSS electrodes minimizes the thermal noise and lowers the amplitude detection limit of the sensor. The electrode noise decreases with frequency from 548 nV r.m.s at 0.1 Hz to a minimum of 6 nV r.m.s for frequencies higher than 100 Hz. This low noise makes it possible to measure low frequency bioelectrical communication signals, typical of non-electrogenic cells, that have until now been difficult to explore using metallic-based microelectrode arrays. The performance of the PEDOT:PSS-based electrodes is demonstrated by recording signals generated by populations of glioma cells with a signal-to-noise ratio as high as 140.
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT/MCTES)Portuguese Foundation for Science and Technology
dc.description.sponsorshipFEDER under the PT 2020 Partnership Agreement
dc.description.sponsorship"Implantable organic devices for advanced therapies", INNOVATE [PTDC/EEIAUT/5442/2014]
dc.description.sponsorshipInstituto de Telecomunicacoes, IT [UIDB/EEA/50008/2020]
dc.description.sponsorshipCentro de Ciencias do Mar, CCMar [UIDB/Multi/04326/2020]
dc.description.sponsorshipCICECO -Aveiro Institute of Materials [UIDB/50011/2020, UIDP/50011/2020]
dc.description.sponsorshipFCT, under the "Norma Transit.oria" project CT0020 [DL57/2016/CP1361]
dc.description.sponsorshipFCTPortuguese Foundation for Science and TechnologyEuropean Commission [SFRH/BD/148688/2019]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.orgel.2020.105882
dc.identifier.issn1566-1199
dc.identifier.urihttp://hdl.handle.net/10400.1/16374
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectPEDOT:PSS
dc.subjectPrinted electronics
dc.subjectBacterial cellulose
dc.subjectExtra-cellular electrodes
dc.subjectNon-excitable cells
dc.subject.otherMaterials Science
dc.titleUltra-low noise PEDOT:PSS electrodes on bacterial cellulose: A sensor to access bioelectrical signals in non-electrogenic cells
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage105882
oaire.citation.titleOrganic Electronics
oaire.citation.volume85
person.familyNameFélix
person.familyNameHubbard
person.familyNamePower
person.givenNameRute
person.givenNamePeter
person.givenNameDeborah Mary
person.identifier.ciencia-idFB1A-1325-8E25
person.identifier.ciencia-id951F-BA4B-A21F
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-4144-3452
person.identifier.orcid0000-0002-3007-4647
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-6164-2013
person.identifier.ridB-2823-2008
person.identifier.scopus-author-id56006773000
person.identifier.scopus-author-id7005928467
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccess
rcaap.typearticle
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relation.isAuthorOfPublication.latestForDiscoveryf599b3ac-806b-4f65-9eb6-f70e68bcb142

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