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European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure

2008Journal article Restricted access
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dc.contributor.authorOliveira, M.
dc.contributor.authorSerafim, Angela
dc.contributor.authorBebianno, Maria João
dc.contributor.authorPacheco, M.
dc.contributor.authorSantos, M. A.
dc.date.accessioned2020-05-06T10:02:01Z
dc.date.available2020-05-06T10:02:01Z
dc.date.issued2008
dc.description.abstractThis study investigated Anguilla anguilla (European eel) physiological and genotoxic responses to copper (Cu) and their relation with metallothionein (MT) protection. Eels were exposed during 7 days to Cu 0.2 micromol/L. MT induction was assessed in gill and liver, revealing significant response only in liver. Endocrine responses displayed a plasma free triiodothyronine (T3) and cortisol significant decrease, though the thyroid-stimulating hormone (TSH) and free thyroxine (T4) concentrations were unaltered. A significant plasma glucose increase was observed whereas lactate was significantly decreased. Despite the absence of DNA integrity decrease in blood, gill, liver and kidney, erythrocytic nuclear abnormalities (ENA) frequency significantly increased in Cu exposed group. MT induction was insufficient to prevent endocrine and metabolic alterations as well as genotoxicity/clastogenicity in blood. However, MT protection was evident in liver by preventing DNA integrity loss. Globally, it was demonstrated that Cu environmentally realistic levels may pose a serious ecological risk to fish.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.ecoenv.2007.10.034pt_PT
dc.identifier.issn0147-6513
dc.identifier.urihttp://hdl.handle.net/10400.1/13841
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0147651307003028?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnguillapt_PT
dc.subjectAnimalspt_PT
dc.subjectBlood glucosept_PT
dc.subjectCell nucleuspt_PT
dc.subjectCopperpt_PT
dc.subjectErythrocytespt_PT
dc.subjectGillspt_PT
dc.subjectHydrocortisonept_PT
dc.subjectKidneypt_PT
dc.subjectLactic acidpt_PT
dc.subjectLiverpt_PT
dc.subjectMetallothioneinpt_PT
dc.subjectMutagenspt_PT
dc.subjectTriiodothyroninept_PT
dc.subjectWater pollutantspt_PT
dc.subjectChemicalpt_PT
dc.subjectAnguilla anguillapt_PT
dc.subjectT3pt_PT
dc.subjectT4pt_PT
dc.subjectCortisolpt_PT
dc.subjectGenotoxicitypt_PT
dc.titleEuropean eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F27584%2F2006/PT
oaire.citation.endPage26pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage20pt_PT
oaire.citation.titleEcotoxicology and Environmental Safetypt_PT
oaire.citation.volume70pt_PT
oaire.fundingStreamSFRH
person.familyNamePereira Serafim
person.familyNameBebianno
person.givenNameMaria Angela
person.givenNameMaria
person.identifier.ciencia-id9C18-090A-5E3D
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-1165-0645
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery0e42fc03-7052-438d-952b-b3caa5bdc36a
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