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Shining the spotlight on NMR metabolic profiling and bioactivities of different solvent extracts of Piliostigma thonningii

2022Journal article Restricted
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dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorZengin, Gokhan
dc.contributor.authorFiorentino, Antonio
dc.contributor.authorVuotto, Chiara
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorJugreet, Sharmeen
dc.contributor.authorGlamočlija, Jasmina
dc.contributor.authorSoković, Marina
dc.contributor.authorEtienne, Ouattara Katinan
dc.contributor.authorPereira, Catarina Guerreiro
dc.contributor.authorCustódio, Luísa
dc.contributor.authorRengasamy, Kannan R.R.
dc.contributor.authorD'Abrosca, Brigida
dc.date.accessioned2022-12-20T09:42:21Z
dc.date.available2022-12-20T09:42:21Z
dc.date.issued2022
dc.description.abstractPiliostigma thonningii (Fabaceae) is a versatile medicinal plant used as a traditional remedy, especially in African countries. In the present study, ethyl acetate, methanolic and water extracts of different parts of (fruits, leaves, stem barks) P. thonningii were evaluated for their bioactive contents, enzyme inhibitory, antioxidant and antimicrobial activities. Antioxidant potentials were also displayed in various methods like phosphomolybdenum assay (0.79-5.94 mmol TE/g), radical scavenging assays (DPPH: 20.39-471.28 mg TE/g; ABTS: 42.43-654.14 mg TE/g); reducing assays (CUPRAC: 102.98-1207.42 mg TE/g; FRAP: 45.30-656.25 mg TE/g) and metal chelating activity (2.55-22.32 mg EDTAE/g). In particular, the methanolic and water extracts showed better antioxidant potential. Except for a few, the extracts were also found to act as inhibitors of enzymes such as acetylcholinesterase (2.35-5.35 mg GALAE/g), butyrylcholinesterase (0.83-13.80 mg GALAE/g), tymsinase (4.03-143.86 mg KAE/g), amylase (0.21-1.39 mmol ACAE/g) and glucosidase (3.52-7.13 mmol ACAE/g). Additionally, all the tested extracts possessed significant antibacterial (minimum inhibitory concentration (MIC) and minimum bactericidal concentration: 0.11-0.61 mg/ml) and antifungal (MIC and minimum fungicidal concentration: 0.04-0.61 mg/ml) effects. Indeed, the data garnered from the present study provides a bright scope for the advanced investigation on this particular plant possessing pharmacologically active traits.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.fbio.2022.101760pt_PT
dc.identifier.issn2212-4292
dc.identifier.urihttp://hdl.handle.net/10400.1/18670
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectPiliostigma thonningiipt_PT
dc.subjectBioactivitiespt_PT
dc.subjectEnzyme inhibitorspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectNMRpt_PT
dc.subjectMetabolic profilingpt_PT
dc.titleShining the spotlight on NMR metabolic profiling and bioactivities of different solvent extracts of Piliostigma thonningiipt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage101760pt_PT
oaire.citation.titleFood Biosciencept_PT
oaire.citation.volume47pt_PT
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication164572fc-85ed-4377-afd0-7ab4c8fdc79f
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery164572fc-85ed-4377-afd0-7ab4c8fdc79f

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