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Assessing the effects of the cytostatic drug 5-Fluorouracil alone and in a mixture of emerging contaminants on the mussel Mytilus galloprovincialis

2022-07Journal article Restricted access
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dc.contributor.authorGonçalves, Joanna M.
dc.contributor.authorBeckmann, Clara
dc.contributor.authorBebianno, Maria
dc.date.accessioned2022-12-05T14:00:32Z
dc.date.available2022-12-05T14:00:32Z
dc.date.issued2022-07
dc.description.abstractThe assessment of contaminants of emerging concern, alone and in mixtures, and their effects on marine biota requires attention. 5-Fluorouracil is a cytostatic category 3 anti-cancer medication (IARC) that is used to treat a variety of cancers, including colon, pancreatic, and breast cancer. In the presence of other pollutants, this pharmaceutical can interact and form mixtures of contaminants, such as adhering to plastics and interaction with metal nanoparticles. This study aimed to comprehend the effects of 5-Fluorouracil (5FU; 10 ng/L) and a mixture of emerging contaminants (Mix): silver nanoparticles (nAg; 20 nm; 10 mu g/L), polystyrene nanoparticles (nPS; 50 nm; 10 mu g/L) and 5FU (10 ng/L), in an in vivo (21 days) exposure of the mussel Mytilus galloprovincialis. A multibiomarker approach namely genotoxicity, the antioxidant defence system (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidases (GPx), glutathione - S - transferases (GST) activities), and oxidative damage (LPO) was used to assess the effects in gills and digestive gland of mussels. Both treatments cause genotoxicity in mussel's haemolymph, and antagonism between contaminants was observed in the Mix. Genotoxicity observed confirms 5FU's mode of action (MoA) by DNA damage. The antioxidant defence system of mussels exposed to 5FU kicked in and counter balanced ROS generated during the exposure, though the same was not seen in Mix-exposed mussels. Mussels were able to withstand the effects of the single compound but not the effects of the Mix. For oxidative stress and damage, the interactions of the components of the mixture have a synergistic effect.pt_PT
dc.description.sponsorshipJPIOCEANS/0005/2020
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.chemosphere.2022.135462pt_PT
dc.identifier.eissn1879-1298
dc.identifier.urihttp://hdl.handle.net/10400.1/18575
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAquatic Research Infrastructure Network
dc.relationCentre for Marine and Environmental Research (CIMA)
dc.subjectEmerging contaminantspt_PT
dc.subjectAnti-cancer drugspt_PT
dc.subjectNanoplasticspt_PT
dc.subjectMetal nanoparticlespt_PT
dc.subjectTertiary mixturespt_PT
dc.subjectMediterranean musselpt_PT
dc.titleAssessing the effects of the cytostatic drug 5-Fluorouracil alone and in a mixture of emerging contaminants on the mussel Mytilus galloprovincialispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardTitleCentre for Marine and Environmental Research (CIMA)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0069%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00350%2F2020/PT
oaire.citation.startPage135462pt_PT
oaire.citation.titleChemospherept_PT
oaire.citation.volume305pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRibeiro Gonçalves
person.familyNameBebianno
person.givenNameJoanna Melissa
person.givenNameMaria
person.identifier.ciencia-id2D1D-F33A-FB48
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-3242-1032
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isProjectOfPublication5af011f9-3888-449a-a18c-d08b59e87091
relation.isProjectOfPublication607b395b-b4ff-4b27-b6e4-779cdea78d97
relation.isProjectOfPublication.latestForDiscovery5af011f9-3888-449a-a18c-d08b59e87091

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