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Coronal brain atlas in stereotaxic coordinates of the African spiny mouse, acomys cahirinus

2022-04Journal article Restricted access
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dc.contributor.authorVitorino, Marta
dc.contributor.authorS, Simão
dc.contributor.authorMoreira, João B.
dc.contributor.authorNogueira‐Rodrigues, Joana
dc.contributor.authorSilva, Joana A
dc.contributor.authorSofia Lourenço, Ana
dc.contributor.authorVitor Fernandes, Dr
dc.contributor.authorSousa, Monica M.
dc.contributor.authorTiscornia, Gustavo
dc.contributor.authorAraújo, Inês Maria
dc.date.accessioned2022-09-20T13:06:28Z
dc.date.available2022-09-20T13:06:28Z
dc.date.issued2022-04
dc.description.abstractThe African spiny mouse (Acomys cahirinus) is an emerging model of mammalian epimorphic regeneration that has aroused the interest of the scientific community in the last decade. To date, studies on brain repair have been hindered by the lack of knowledge on the neuroanatomy of this species. Here, we present a coronal brain atlas in stereotaxic coordinates, which allows for three-dimensional identification and localization of the brain structures of this species. The brain of 12-week-old spiny mice was mapped in stereotaxic coordinates using cresyl violet-stained brain sections obtained from coronal cryosectioning of the brain after transcardial perfusion with fixative. The atlas is presented in 42 plates representing sections spaced 240 mu m apart. Stereotaxic coordinates were validated using both a model of Parkinsonian lesion of the striatum with 6-hydroxydopamine and labeling of the corticospinal tract in the spiny mouse spinal cord using AAV1/2-GFP intracortical injections. This work presents a new tool in A. cahirinus neurobiology and opens new avenues of research for the investigation of the regenerative ability of A. cahirinus in models of brain disorders.pt_PT
dc.description.sponsorshipMC-39-2019; PPBI-POCI-01-0145-FEDER-022122
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/cne.25329pt_PT
dc.identifier.eissn1096-9861
dc.identifier.urihttp://hdl.handle.net/10400.1/18266
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationRegeneration in the African Spiny Mouse
dc.relationIdentification of the transcriptomic response during regeneration of dopaminergic neurons in Acomys cahirinus following lesion of the substantia nigra
dc.relationIdentifying molecules and mechanisms enhancing axon growth and antagonizing axon growth inhibition: a combined approach
dc.subjectAcomys cahirinuspt_PT
dc.subjectAtlaspt_PT
dc.subjectAtlaspt_PT
dc.subjectBrainpt_PT
dc.subjectDisease modelspt_PT
dc.subjectEpimorphic regenerationspt_PT
dc.subjectTereotaxic surgerypt_PT
dc.titleCoronal brain atlas in stereotaxic coordinates of the African spiny mouse, acomys cahirinuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleRegeneration in the African Spiny Mouse
oaire.awardTitleIdentification of the transcriptomic response during regeneration of dopaminergic neurons in Acomys cahirinus following lesion of the substantia nigra
oaire.awardTitleIdentifying molecules and mechanisms enhancing axon growth and antagonizing axon growth inhibition: a combined approach
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-ANM%2F0697%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130770%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F131565%2F2017/PT
oaire.citation.endPage2237pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2215pt_PT
oaire.citation.titleJournal of Comparative Neurologypt_PT
oaire.citation.volume530pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameVitorino
person.familyNameSimao
person.familyNameMoreira
person.familyNameSilva
person.familyNameLourenço
person.familyNameE. Fernandes
person.familyNameTiscornia
person.familyNamePombinho de Araújo
person.givenNameMarta
person.givenNameSonia
person.givenNameJoão
person.givenNameJoana
person.givenNameAna Sofia
person.givenNameVitor
person.givenNameGustavo
person.givenNameInês Maria
person.identifier170713
person.identifierF-4703-2012
person.identifier.ciencia-id4615-FF5B-E951
person.identifier.ciencia-id3811-AC60-F24D
person.identifier.ciencia-id7818-59E3-E4EE
person.identifier.ciencia-idD11F-D4CA-2947
person.identifier.orcid0000-0001-8563-8975
person.identifier.orcid0000-0002-0245-0633
person.identifier.orcid0000-0002-7736-844X
person.identifier.orcid0000-0003-0306-2146
person.identifier.orcid0000-0003-2882-6026
person.identifier.orcid0000-0001-5179-2122
person.identifier.orcid0000-0002-1841-5330
person.identifier.orcid0000-0002-2438-0111
person.identifier.ridU-9947-2018
person.identifier.scopus-author-id24067982400
person.identifier.scopus-author-id56822397300
person.identifier.scopus-author-id36155199000
person.identifier.scopus-author-id6507863404
person.identifier.scopus-author-id56271084100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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