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Dietary glucose stimulus at larval stage modifies the carbohydrate metabolic pathway in gilthead seabream (Sparus aurata) juveniles: An in vivo approach using C-14-starch

2016-07Journal article Restricted access
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dc.contributor.authorRocha, Filipa
dc.contributor.authorDias, Jorge
dc.contributor.authorGeurden, Inge
dc.contributor.authorDinis, Maria Teresa
dc.contributor.authorPanserat, Stephane
dc.contributor.authorEngrola, S.
dc.date.accessioned2017-04-07T15:55:49Z
dc.date.available2017-04-07T15:55:49Z
dc.date.issued2016-07
dc.description.abstractThe concept of nutritional programming was investigated in order to enhance the use of dietary carbohydrates in gilthead seabream juveniles. We assessed the long-term effects of high-glucose stimuli, exerted at the larval stage, on the growth performance, nutrient digestibility and metabolic utilization and gene expression of seabream juveniles, challenged with a high-carbohydrate intake. During early development, a group of larvae (control, CTRL) were kept under a rich-protein-lipid feeding regime whereas another group (GLU) was subjected to high-glucose stimuli, delivered intermittently over time. At juvenile stage, triplicate groups (IBW: 2.5 g) from each fish nutritional background were fed a high-protein (59.4%) low-carbohydrate (2.0%) diet before being subjected to a low-protein (43.0%) high-carbohydrate (33.0%) dietary challenge for 36-days. Fish from both treatments increased by 8-fold their initial body weight, but neither growth rate, feed intake, feed and protein efficiency, nutrient retention (except lipids) nor whole-body composition were affected (P (>) 0.05) by fish early nutritional history. Nutrient digestibility was also similar among both groups. The metabolic fate of C-14-starch and C-14-amino acids tracers was estimated; GLU juveniles showed higher absorption of starch-derived glucose in the gut, suggesting an enhanced digestion of carbohydrates, while amino acid use was not affected. Moreover, glucose was less used for de novo synthesis of hepatic proteins and muscle glycogen from GLU fish (P < 0.05). Our metabolic data suggests that the early glucose stimuli may alter carbohydrate utilization in seabream juveniles. (C) 2016 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.cbpa.2016.07.016
dc.identifier.issn1095-6433
dc.identifier.urihttp://hdl.handle.net/10400.1/9230
dc.language.isoeng
dc.peerreviewedyes
dc.relationEARLY NUTRITIONAL PROGRAMMING IN FISH: TAILORING THE METABOLIC USE OF DIETARY GLUCOSE
dc.relation.isbasedonWOS:000385325700024
dc.titleDietary glucose stimulus at larval stage modifies the carbohydrate metabolic pathway in gilthead seabream (Sparus aurata) juveniles: An in vivo approach using C-14-starch
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEARLY NUTRITIONAL PROGRAMMING IN FISH: TAILORING THE METABOLIC USE OF DIETARY GLUCOSE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F74921%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00482%2F2014%2FCP1217%2FCT0005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.citation.endPage199
oaire.citation.startPage189
oaire.citation.titleComparative Biochemistry and Physiology, Part A
oaire.citation.volume201
oaire.fundingStreamInvestigador FCT
oaire.fundingStream5876
person.familyNameRocha
person.familyNameDinis
person.familyNameEngrola
person.givenNameFilipa
person.givenNameMaria Teresa
person.givenNameSofia
person.identifier237846
person.identifier.ciencia-id5414-4ACF-BF90
person.identifier.ciencia-idA610-29E7-9B83
person.identifier.orcid0000-0002-7531-9302
person.identifier.orcid0000-0001-7813-1324
person.identifier.orcid0000-0002-5244-5541
person.identifier.ridA-2485-2012
person.identifier.scopus-author-id7004150905
person.identifier.scopus-author-id8669620600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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