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The vertebrate Embryo Clock: Common players dancing to a different beat

2022Journal article Open access
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dc.contributor.authorCarraco, Gil
dc.contributor.authorMartins-Jesus, Ana P.
dc.contributor.authorAndrade, Raquel P.
dc.date.accessioned2023-01-17T10:09:32Z
dc.date.available2023-01-17T10:09:32Z
dc.date.issued2022
dc.description.abstractVertebrate embryo somitogenesis is the earliest morphological manifestation of the characteristic patterned structure of the adult axial skeleton. Pairs of somites flanking the neural tube are formed periodically during early development, and the molecular mechanisms in temporal control of this early patterning event have been thoroughly studied. The discovery of a molecular Embryo Clock (EC) underlying the periodicity of somite formation shed light on the importance of gene expression dynamics for pattern formation. The EC is now known to be present in all vertebrate organisms studied and this mechanism was also described in limb development and stem cell differentiation. An outstanding question, however, remains unanswered: what sets the different EC paces observed in different organisms and tissues? This review aims to summarize the available knowledge regarding the pace of the EC, its regulation and experimental manipulation and to expose new questions that might help shed light on what is still to unveil.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fcell.2022.944016pt_PT
dc.identifier.issn2296-634X
dc.identifier.urihttp://hdl.handle.net/10400.1/18823
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationRegulating the pace of the Embryo Clock: RNA molecules in temporal control of vertebrate development
dc.relationTIMING CELL DIFFERENTIATON: Gene Regulatory Network in Temporal Control of Mesoderm Specification
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTemporal controlpt_PT
dc.subjectEmbryo clockpt_PT
dc.subjectSomitogenesispt_PT
dc.subjectNegative feedback regulationpt_PT
dc.subjectNotch signallingpt_PT
dc.subjectHESpt_PT
dc.titleThe vertebrate Embryo Clock: Common players dancing to a different beatpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleRegulating the pace of the Embryo Clock: RNA molecules in temporal control of vertebrate development
oaire.awardTitleTIMING CELL DIFFERENTIATON: Gene Regulatory Network in Temporal Control of Mesoderm Specification
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F101609%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BID%2F5410%2F2014/PT
oaire.citation.titleFrontiers in Cell and Developmental Biologypt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamOE
oaire.fundingStream3599-PPCDT
person.familyNameCarraco
person.familyNameAndrade
person.givenNameGil
person.givenNameRaquel
person.identifier.ciencia-id2312-360B-227A
person.identifier.orcid0000-0002-5008-6338
person.identifier.orcid0000-0002-0397-5917
person.identifier.scopus-author-id7103114918
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb7311422-a085-4252-84fc-f8487296b474
relation.isAuthorOfPublicationf2d3fc39-a8f6-4d83-9e60-2e2fdfbc2b4a
relation.isAuthorOfPublication.latestForDiscoveryb7311422-a085-4252-84fc-f8487296b474
relation.isProjectOfPublication3801ffea-1906-4102-a0a7-de5742036000
relation.isProjectOfPublicationf3a8ba92-68e5-4983-a086-3c3472579529
relation.isProjectOfPublication.latestForDiscoveryf3a8ba92-68e5-4983-a086-3c3472579529

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