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Real-world healthcare resource use associated with recurrent or metastatic head and neck cancer patients care in Portugal—TRACE Study

2024-07-26Journal article Open Access
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dc.contributor.authorTeixeira, Maria Margarida
dc.contributor.authorDias, João
dc.contributor.authorAndré, Teresa
dc.contributor.authorJoaquim, Ana
dc.contributor.authorFernandes, Ricardo
dc.contributor.authorMagalhães, Joana
dc.contributor.authorMarreiros, Laura
dc.contributor.authorPinto, Leonor
dc.contributor.authorRibeiro, Leonor
dc.contributor.authorNogueira, Mafalda
dc.contributor.authorMorais, Catarina
dc.date.accessioned2024-12-06T11:39:00Z
dc.date.available2024-12-06T11:39:00Z
dc.date.issued2024-07-26
dc.description.abstractRecurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a challenging disease, requiring personalized management by a multidisciplinary team. The aim of this retrospective multicentric study was to characterize real-world healthcare resource use and patient care for R/M HNSCC in Portugal during the first year after diagnosis. A total of 377 patients ineligible for curative treatment were included, mostly male (92.8%), aged 50-69 years (74.5%), with heavy alcohol (72.7%) or smoking habits (89.3%). Oropharynx (33.2%) and oral cavity (28.7%) were primary tumor locations, with lung metastases being the most common (61.4%). Eligible patients for systemic treatment with palliative intent (80.6%) received up to four treatment lines, with varied regimens. Platinum-based combination chemotherapy dominated first-line treatment (>70%), while single-agent chemotherapy and anti-PD1 immunotherapy were prevalent in later lines. Treatment approaches were uniform across disease stages and primary tumor locations but varied geographically. Treated patients received more multidisciplinary support than those who were ineligible. This study provides the first Portuguese real-world description of R/M HNSCC patient characteristics, treatment patterns, and supportive care during the year after diagnosis, highlighting population heterogeneity and aiming to improve patient management.eng
dc.identifier.doi10.3390/curroncol31080318
dc.identifier.issn1718-7729
dc.identifier.urihttp://hdl.handle.net/10400.1/26410
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://www.mdpi.com/1718-7729/31/8/318
dc.relation.ispartofCurrent Oncology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHead and neck
dc.subjectHealthcare resources
dc.subjectPatient management
dc.subjectReal-world
dc.subjectRecurrent or metastatic disease
dc.titleReal-world healthcare resource use associated with recurrent or metastatic head and neck cancer patients care in Portugal—TRACE Studyeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4283
oaire.citation.issue8
oaire.citation.startPage4271
oaire.citation.titleCurrent Oncology
oaire.citation.volume31
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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