Repository logo
 
Publication

Anticancer activity of rutin and its combination with ionic liquids on renal cells

2020-02Journal article Open access
Simple item page
dc.contributor.authorCaparica, Rita
dc.contributor.authorJúlio, Ana
dc.contributor.authorAraújo, Maria Eduarda Machado
dc.contributor.authorBaby, André Rolim
dc.contributor.authorFonte, Pedro
dc.contributor.authorCosta, João Guilherme
dc.contributor.authorSantos de Almeida, Tânia
dc.date.accessioned2020-04-15T09:34:23Z
dc.date.available2020-04-15T09:34:23Z
dc.date.issued2020-02
dc.description.abstractThe renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC. Rutin, a bioflavonoid widely found in nature, has shown promising anticancer properties, but with limited applicability due to its poor water solubility and pharmacokinetics. Thus, the potential anticancer effects of rutin toward a human renal cancer cell line (786-O), while considering its safety in Vero kidney cells, was assessed, as well as the applicability of ionic liquids (ILs) to improve drug delivery. Rutin (up to 50 µM) did not show relevant cytotoxic effects in Vero cells. However, in 786-O cells, a significant decrease in cell viability was already observed at 50 µM. Moreover, exposure to rutin caused a significant increase in the sub-G1 population of 786-O cells, reinforcing the possible anticancer activity of this biomolecule. Two choline-amino acid ILs, at non-toxic concentrations, enhanced rutin's solubility/loading while allowing the maintenance of rutin's anticancer effects. Globally, our findings suggest that rutin may have a beneficial impact against RCC and that its combination with ILs ensures that this poorly soluble drug is successfully incorporated into ILs-nanoparticles hybrid systems, allowing controlled drug delivery.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia (FCT, Portugal): UID/DTP/04567/2019/ UIDB/00100/2020/ UIDB/04565/2020. ALIES grant PADDIC 2018-2019pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.3390/biom10020233pt_PT
dc.identifier.issn2218-273X
dc.identifier.urihttp://hdl.handle.net/10400.1/13708
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentro de Investigação em Biociências e Tecnologias da Saúde
dc.relationCentro de Química Estrutural
dc.relationInstitute for Bioengineering and Biosciences
dc.relation.publisherversionhttps://www.mdpi.com/2218-273X/10/2/233pt_PT
dc.subjectRutinpt_PT
dc.subjectRenal cancerpt_PT
dc.subject786-O cellspt_PT
dc.subjectVero cellspt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectCell cyclept_PT
dc.subjectIonic liquidspt_PT
dc.subjectSolubilitypt_PT
dc.subjectILs–nanoparticles hybrid systempt_PT
dc.titleAnticancer activity of rutin and its combination with ionic liquids on renal cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentro de Investigação em Biociências e Tecnologias da Saúde
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04567%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage233pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFonte
person.givenNamePedro
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id55146900200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a5c2b2-9112-4bf4-8618-8c2051bbc116
relation.isAuthorOfPublication.latestForDiscoverya5a5c2b2-9112-4bf4-8618-8c2051bbc116
relation.isProjectOfPublicationf97477c5-5599-4ba5-a9f9-192dd295a466
relation.isProjectOfPublicationdf39fd72-bd68-4aaf-8b89-25d17b8c5ebd
relation.isProjectOfPublication2aa82082-d177-45a7-bcfb-53835259cdf7
relation.isProjectOfPublication.latestForDiscoveryf97477c5-5599-4ba5-a9f9-192dd295a466

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
biomolecules-10-00233-v2.pdf
Size:
2 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.46 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)