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Antioxidant activity, enzyme inhibition, photoprotection, cytotoxicity, and phytochemical profiling of sea lavender (Limonium algarvense Erben) seed extracts for dermo-cosmetic use

2024-11-08Journal article Open access
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dc.contributor.authorLescano, Leonardo
dc.contributor.authorCziáky, Zoltán
dc.contributor.authorKurt-Celep, İnci
dc.contributor.authorZengin, Gökhan
dc.contributor.authorFernandes, Eliana
dc.contributor.authorTrentin, Riccardo
dc.contributor.authorGuerreiro Pereira, Catarina Alexandra
dc.contributor.authorCustódio, Luísa
dc.contributor.authorRodrigues, Maria João
dc.date.accessioned2025-01-29T14:32:58Z
dc.date.available2025-01-29T14:32:58Z
dc.date.issued2024-11-08
dc.description.abstractDespite sea lavender being a medicinal species, research on its seeds' biological properties and chemical composition is unexplored. Thus, this study evaluated the effect of different extraction solvents on the biological activities and chemical profile of greenhouse-cultivated sea lavender seeds, aiming at their potential use as a dermo-cosmetic ingredient. Therefore, ethyl acetate, acetone, ethanol, and water extracts were examined for their antioxidant activity, enzyme inhibition, photoprotection, and cytotoxicity, followed by phytochemical analysis through spectrophotometric methods, further detailed by Ultrahigh-Performance Liquid Chromatography Coupled with Electrospray Ionization Mass/Mass Spectrometry (UHPLC-Esi-MS/MS).ResultsThe water extract demonstrated significant antioxidant activity, evidenced by low half maximal effective concentration (EC50) values in scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, reducing iron and chelating copper (296, 478, 230 and 678 mu g/mL, respectively). The ethanol extract was more effective in inhibiting cosmetic-related enzymes, particularly elastase and hyaluronidase (2.18 and 3.21 mu g/mL, respectively). The water and acetone extracts had the highest sun protection factors (23.2 and 18.9, respectively). All the extracts had nil to weak cytotoxicity (70-120% cell viability) towards mammalian cell lines. The water extract had the highest phenolics and condensed tannins (115 and 78.30 mg/g extract, respectively), while the ethanol contained the most flavonoids (62.73 mg/g extract). UHPLC-ESI-MS/MS analysis identified ethyl gallate, myricetin, rutin, and quercetin as major components of the ethanol extract, whereas myricetin-O-rutinoside isomers are predominant in the water extract.ConclusionsThese findings highlight the potential of greenhouse-cultivated sea lavender seeds as potential dermo-cosmetic ingredients, with ethanol and water extracts demonstrating superior biological activities and chemical profiles, significantly contributing to general skin health and protection.eng
dc.description.sponsorshipCEECIND/00425/2017
dc.identifier.doi10.1186/s43088-024-00576-9
dc.identifier.issn2314-8543
dc.identifier.urihttp://hdl.handle.net/10400.1/26696
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringerOpen
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationXTREMEVEGGIES - SUSTAINABLE HALOPHYTES CULTIVATION TARGETING MULTIPLE COMMERCIAL PURPOSES
dc.relation.ispartofBeni-Suef University Journal of Basic and Applied Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHalophytes
dc.subjectSalt tolerant plants
dc.subjectSkincare
dc.subjectPhotoprotective properties
dc.subjectAnti-hyperpigmentation
dc.subjectAnti-ageing
dc.subjectFlavonoids
dc.titleAntioxidant activity, enzyme inhibition, photoprotection, cytotoxicity, and phytochemical profiling of sea lavender (Limonium algarvense Erben) seed extracts for dermo-cosmetic useeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleXTREMEVEGGIES - SUSTAINABLE HALOPHYTES CULTIVATION TARGETING MULTIPLE COMMERCIAL PURPOSES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151301%2F2021/PT
oaire.citation.issue1
oaire.citation.startPage112
oaire.citation.titleBeni-Suef University Journal of Basic and Applied Sciences
oaire.citation.volume13
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFernandes
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.familyNameRodrigues
person.givenNameEliana
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.givenNameMaria João
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person.identifier.orcid0000-0003-4083-8353
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person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
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project.funder.nameFundação para a Ciência e a Tecnologia
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