Repository logo
 
Publication

Euphorbia denticulata Lam.: a promising source of phyto-pharmaceuticals for the development of novel functional formulations

2017-03Journal article Restricted
Simple item page
dc.contributor.authorZengin, Gokhan
dc.contributor.authorUysal, Ahmet
dc.contributor.authorAktumsek, Abdurrahman
dc.contributor.authorMocan, Andrei
dc.contributor.authorMollica, Adriano
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorCustódio, Luísa
dc.contributor.authorNeng, Nuno R.
dc.contributor.authorNogueira, Jose M. F.
dc.contributor.authorAumeeruddy-Elalfi, Zaahira
dc.contributor.authorMahomoodally, M. Fawzi
dc.date.accessioned2019-11-20T15:07:47Z
dc.date.available2019-11-20T15:07:47Z
dc.date.issued2017-03
dc.description.abstractIn this study, Methanolic extracts of Euphorbia denticulata parts (flowers, leaf, stem, and mix of aerial parts) were assessed for a panoply of bioactivities. Inhibitory potential against key enzymes involved in diabetes (alpha-glucosidase and alpha-amylase), obesity (pancreatic lipase), neurodegenerative diseases (cholinesterases), and hyperpigmentation (tyrosinase) was evaluated. The antioxidant and antibacterial properties were also assessed. The total phenolic, flavonoid, and phytochemical profile were established using HPLC/DAD and molecular modelling studies on specific target compounds were performed in silico. The flower extract was found to be rich in phenolics and flavonoids, (60.11 +/- 1.40 mgGAE/g and 42.04 +/- 0.16 mgRE/g respectively), which tend to correlate with the high radical scavenging activity of this extract (120.34 +/- 3.33 mgTE/g and 165.42 +/- 2.16 mgTE/g for DPPH and ABTS respectively). Catechin, epicatechin, gallic acid, p-OH-Benzoic acid, rosmarinic acid, and epigallocatechin gallate, found in significant abundance in the extracts were assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. The extracts were moderately effective with MIC values ranging between 1.56 to 6.25 mg/ml, but potent growth inhibitors of MRSA strains. Results amassed herein can be used as a stimulus for further studies geared towards the development of novel phyto-pharmaceuticals. (C) 2016 Elsevier Masson SAS. All rights reserved.
dc.identifier.doi10.1016/j.biopha.2016.12.063
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.urihttp://hdl.handle.net/10400.1/13212
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier France
dc.subjectAlpha-glucosidase
dc.subjectPancreatic lipase
dc.subjectRosmarinic acid
dc.subjectIn-vitro
dc.subjectAntioxidant activities
dc.subjectCrystal-structure
dc.subjectMedicinal-plants
dc.subjectRat-brain
dc.subjectPolyphenols
dc.subjectInhibition
dc.titleEuphorbia denticulata Lam.: a promising source of phyto-pharmaceuticals for the development of novel functional formulations
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage36
oaire.citation.startPage27
oaire.citation.titleBiomedicine & Pharmacotherapy
oaire.citation.volume87
person.familyNameCustódio
person.givenNameLuísa
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id15831018900
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscoveryf9cfed0f-6b67-413e-988c-ac7397183471

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
13212 linha 53 Zengin-2017-Euphorbia-denticulata-lam-a-promisi.pdf
Size:
2.16 MB
Format:
Adobe Portable Document Format
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)