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Antimalarial agents as therapeutic tools against toxoplasmosis: a short bridge between two distant illnesses

2020Journal article Open Access
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dc.contributor.authorSecrieru, Alina
dc.contributor.authorCosta, Inês C. C.
dc.contributor.authorO'Neill, Paul M.
dc.contributor.authorCristiano, Maria De Lurdes
dc.date.accessioned2020-05-29T13:57:18Z
dc.date.available2020-05-29T13:57:18Z
dc.date.issued2020
dc.description.abstractToxoplasmosis is an infectious disease with paramount impact worldwide, affecting many vulnerable populations and representing a significant matter of concern. Current therapies used against toxoplasmosis are based essentially on old chemotypes, which fail in providing a definitive cure for the disease, placing the most sensitive populations at risk for irreversible damage in vital organs, culminating in death in the most serious cases. Antimalarial drugs have been shown to possess key features for drug repurposing, finding application in the treatment of other parasite-borne illnesses, including toxoplasmosis. Antimalarials provide the most effective therapeutic solutions against toxoplasmosis and make up for the majority of currently available antitoxoplasmic drugs. Additionally, other antiplasmodial drugs have been scrutinized and many promising candidates have emanated in recent developments. Available data demonstrate that it is worthwhile to explore the activity of classical and most recent antimalarial chemotypes, such as quinolines, endoperoxides, pyrazolo[1,5-a]pyrimidines, and nature-derived peptide-based parasiticidal agents, in the context of toxoplasmosis chemotherapy, in the quest for encountering more effective and safer tools for toxoplasmosis control or eradication.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia (FCT): UID/MULTI/04326/2019 (CCMAR), UID/QUI/00313/2019 (CQC), PTDC/MAR-BIO/4132/2014, SFRH/BD/140249/2018 (AS).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules25071574pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.1/13971
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subjectToxoplasma gondiipt_PT
dc.subjectPyrazolo[1; 5-a]pyrimidinespt_PT
dc.subjectAntimicrobial peptidespt_PT
dc.subjectAntimalarial drugspt_PT
dc.subjectPlasmodium spppt_PT
dc.subjectDrug repurposingpt_PT
dc.subjectQuinolinespt_PT
dc.subjectEndochin-like quinolonespt_PT
dc.subjectEndoperoxidespt_PT
dc.titleAntimalarial agents as therapeutic tools against toxoplasmosis: a short bridge between two distant illnessespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.startPage1574pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume25pt_PT
person.familyNameSecrieru
person.familyNameCristiano
person.givenNameAlina
person.givenNameMaria de Lurdes
person.identifier.ciencia-id0014-D52F-FF47
person.identifier.ciencia-idE411-6006-5A01
person.identifier.orcid0000-0002-9447-2855
person.identifier.ridG-2345-2012
person.identifier.scopus-author-id9238724800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdd633f1f-1a9f-41c5-bce7-72fe2c045c71
relation.isAuthorOfPublicationb16751a6-748e-44b0-9c59-058cbd5b2cc3
relation.isAuthorOfPublication.latestForDiscoveryb16751a6-748e-44b0-9c59-058cbd5b2cc3

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