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Cytotoxic, antioxidant, and enzyme inhibitory activities of centaurea stapfiana extracts and their HPLC-ESI-QTOF-MS profiles: Insights into an unexplored centaurea species

2024-12Journal article Restricted access
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dc.contributor.authorZengin, Gokhan
dc.contributor.authorFernández-Ochoa, Álvaro
dc.contributor.authorCádiz-Gurrea, María de la Luz
dc.contributor.authorJiménez, Francisco-Javier Leyva
dc.contributor.authorUba, Abdullahi Ibrahim
dc.contributor.authorAk, Gunes
dc.contributor.authorSoomro, Sanam Iram
dc.contributor.authorBalos, Maruf
dc.contributor.authorCakilcioglu, Ugur
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorGuerreiro Pereira, Catarina Alexandra
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2024-10-23T12:33:56Z
dc.date.available2024-10-23T12:33:56Z
dc.date.issued2024-12
dc.description.abstractThe members of the genus Centaurea have a great interest in pharmaceutical and nutraceutical fields due to their biological potential. Based on this information, we aimed to evaluate the biological properties (antioxidant, enzyme inhibition and cytotoxicity) and chemical profile of the extract of Centaurea stapfiana, , an unstudied species. The highest total phenolic content was found in the ethanol/water extract with 32.17 mg GAE/g. A total of 102 of them were identified by HPLC-ESI-QTOF-MS analysis. These compounds were mainly hydroxybenzoic acid and hydroxycinnamic acid as well as flavonoids. In the antioxidant tests, the ethanol/water extract had the best free radical scavenging and reducing ability. However, in the enzyme inhibition test, the ethanol extract was the most active. The extracts were also tested on two tumour cell lines (RAW 264.7 and HepG2) and one non- tumour cell line (S17). The ethanol extract showed the promising effect on HepG2 (cell viability: 28.6 % at 50 g/ml). Furthermore, we examined the interactions between the compounds and enzymatic and cellular targets. A good interaction was found between quercetin-3-xylosyl-(1- > 6)-glucoside and iNOS. In summary, our results suggest that C. stapfiana can be considered as a versatile raw material for the development of health- promoting applications in the pharmaceutical and cosmeceutical fields.eng
dc.identifier.doi10.1016/j.fitote.2024.106207
dc.identifier.issn0367-326X
dc.identifier.urihttp://hdl.handle.net/10400.1/26131
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.ispartofFitoterapia
dc.rights.uriN/A
dc.subjectCentaurea
dc.subjectFlavonoids
dc.subjectAntioxidants
dc.subjectHepG2
dc.subjectiNOS
dc.subjectHealth-promoting agents
dc.titleCytotoxic, antioxidant, and enzyme inhibitory activities of centaurea stapfiana extracts and their HPLC-ESI-QTOF-MS profiles: Insights into an unexplored centaurea specieseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage106207
oaire.citation.titleFitoterapia: Bioactives from plants and fungi
oaire.citation.volume179
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.givenNameMaria João
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.identifierR-004-VNG
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublication164572fc-85ed-4377-afd0-7ab4c8fdc79f
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery12c32925-de9e-4289-bdd5-1d655d7a278c

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