Repository logo
 
Publication

TRIB2 as a biomarker for diagnosis and progression of melanoma

2015-04Journal article Open Access
Simple item page
dc.contributor.authorHill, Richard
dc.contributor.authorKalathur, Ravi Kiran Reddy
dc.contributor.authorColaco, Laura
dc.contributor.authorBrandao, Ricardo
dc.contributor.authorUgurel, Selma
dc.contributor.authorFutschik, Matthias
dc.contributor.authorLink, Wolfgang
dc.date.accessioned2018-12-07T14:52:28Z
dc.date.available2018-12-07T14:52:28Z
dc.date.issued2015-04
dc.description.abstractMalignant melanoma is the most deadly form of skin cancer. There is a critical need to identify the patients that could be successfully treated by surgery alone and those that require adjuvant treatment. In this study, we demonstrate that the expression of tribbles2 (TRIB2) strongly correlates with both the presence and progression of melanocyte-derived malignancies. We examined the expression of TRIB2 in addition to 12 previously described melanoma biomarkers across three independent full genome microarray studies. TRIB2 expression was consistently and significantly increased in benign nevi and melanoma, and was highest in samples from patients with metastatic melanoma. The expression profiles for the 12 biomarkers were poorly conserved throughout these studies with only TYR, S100B and SPP1 showing consistently elevated expression in metastatic melanoma versus normal skin. Strikingly we confirmed these findings in 20 freshly obtained primary melanoma tissue samples from metastatic lesions where the expression of these biomarkers were evaluated revealing that TRIB2 expression correlated with disease stage and clinical prognosis. Our results suggest that TRIB2 is a meaningful biomarker reflecting diagnosis and progression of melanoma, as well as predicting clinical response to chemotherapy.
dc.description.sponsorshipFundacao para a Ciencia e a Tecnologia (FCT) [PEst-OE/EQB/LA0023/2012, SFRH/BPD/84634/2012, SFRH/BPD/70718/2010]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1093/carcin/bgv002
dc.identifier.issn0143-3334
dc.identifier.issn1460-2180
dc.identifier.urihttp://hdl.handle.net/10400.1/11088
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press
dc.relationSYSTEMS BIOLOGY APPROACH TO UNRAVEL THE MOLECULAR MECHANISMS INVOLVED IN T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCutaneous malignant-melanoma
dc.subjectTyrosinase messenger-Rna
dc.subjectMetastatic melanoma
dc.subjectGene-Expression
dc.subjectPrognostic-significance
dc.subjectPeripheral-blood
dc.subjectS-100 Protein
dc.subjectMarker
dc.subjectTherapy
dc.subjectTumors
dc.titleTRIB2 as a biomarker for diagnosis and progression of melanoma
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSYSTEMS BIOLOGY APPROACH TO UNRAVEL THE MOLECULAR MECHANISMS INVOLVED IN T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F84634%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F70718%2F2010/PT
oaire.citation.endPage477
oaire.citation.issue4
oaire.citation.startPage469
oaire.citation.titleCarcinogenesis
oaire.citation.volume36
oaire.fundingStreamSFRH
person.familyNameFutschik
person.familyNameLink
person.givenNameMatthias
person.givenNameWolfgang
person.identifier803637
person.identifier.ciencia-idA71B-AD01-3501
person.identifier.ciencia-id6910-952E-242A
person.identifier.orcid0000-0002-6245-8071
person.identifier.orcid0000-0002-3340-5165
person.identifier.scopus-author-id14017989400
person.identifier.scopus-author-id35368713800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationd58f3269-c7e1-4c22-b094-5cfe6750821b
relation.isAuthorOfPublication12535e25-d71b-4a7f-9fc9-fff42d47deaf
relation.isAuthorOfPublication.latestForDiscovery12535e25-d71b-4a7f-9fc9-fff42d47deaf
relation.isProjectOfPublication17c0b083-b52b-4765-8284-77d5cb3a77b2
relation.isProjectOfPublication55e70560-7c4e-40bf-8fc7-eb7a93214c3d
relation.isProjectOfPublication.latestForDiscovery55e70560-7c4e-40bf-8fc7-eb7a93214c3d

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
H11088.pdf
Size:
1.98 MB
Format:
Adobe Portable Document Format
Download

Collections

FCB2-Artigos (em revistas ou actas indexadas)