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Ioxynil and diethylstilbestrol impair cardiac performance and shell growth in the mussel Mytilus coruscus

2023-09Journal article Restricted access
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dc.contributor.authorLi, Yi-Feng
dc.contributor.authorLin, Yue-Tong
dc.contributor.authorWang, Yu-Qing
dc.contributor.authorNi, Ji-Yue
dc.contributor.authorPower, Deborah
dc.date.accessioned2023-11-24T11:10:56Z
dc.date.available2023-11-24T11:10:56Z
dc.date.issued2023-09
dc.description.abstractThe herbicide ioxynil (IOX) and the synthetic estrogen diethylstilbestrol (DES) are environmentally relevant contaminants that act as endocrine disruptors (EDCs) and have recently been shown to be cardiovascular disruptors in vertebrates. Mussels, Mytilus coruscus, were exposed to low doses of IOX (0.37, 0.037 and 0.0037 mg/ L) and DES (0.27, 0.027 and 0.0027 mg/L) via the water and the effect monitored by generating whole animal transcriptomes and measuring cardiac performance and shell growth. One day after IOX (0.37 and 0.037 mg/L) and DES (0.27 and 0.027 mg/L) exposure heart rate frequency was decreased in both groups and 0.27 mg/L DES significantly reduced heart rate frequency with increasing time of exposure (P < 0.05) and no acclimatization occurred. The functional effects were coupled to significant differential expression of genes of the serotonergic synapse pathway and cardiac-related genes at 0.027 mg/L DES, which suggests that impaired heart function may be due to interference with neuroendocrine regulation and direct cardiac effect genes. Multiple genes related to detoxifying xenobiotic substances were up regulated and genes related to immune function were down regulated in the DES group (vs. control), indicating that detoxification processes were enhanced, and the immune response was depressed. In contrast, IOX had a minor disrupting effect at a molecular level. Of note was a significant suppression (P < 0.05) by DES of shell growth in juveniles and lower doses (< 0.0027 mg/L) had a more severe effect. The shell growth depression in 0.0027 mg/L DES-treated juveniles was not accompanied by abundant differential gene expression, suggesting that the effect of 0.0027 mg/L DES on shell growth may be direct. The results obtained in the present study reveal for the first time that IOX and DES may act as neuroendocrine disrupters with a broad spectrum of effects on cardiac performance and shell growth, and that DES exposure had a much more pronounced effect than IOX in a marine bivalve.pt_PT
dc.description.sponsorshipNational Key Research and Devel-opment Program of China 2022YFD2401700, National Natural Science Foundation of China (NSFC) 32172992pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.scitotenv.2023.166834pt_PT
dc.identifier.eissn1879-1026
dc.identifier.urihttp://hdl.handle.net/10400.1/20161
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectCardiovascular disruptionpt_PT
dc.subjectDiethylstilbestrolpt_PT
dc.subjectGrowthIoxynilpt_PT
dc.subjectMytilus coruscuspt_PT
dc.subjectNeuroendocrine disruptionpt_PT
dc.titleIoxynil and diethylstilbestrol impair cardiac performance and shell growth in the mussel Mytilus coruscuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage166834pt_PT
oaire.citation.titleScience of The Total Environmentpt_PT
oaire.citation.volume905pt_PT
person.familyNameLi
person.familyNamePower
person.givenNameYi-Feng
person.givenNameDeborah Mary
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-1140-5535
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication103f5490-a2da-47d4-b884-5749ad51a153
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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