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If you cannot beat them, join them: exploring the fruits of the invasive species Carpobrotus edulis (L.) NE Br as a source of bioactive products

2020-02Journal article Restricted
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dc.contributor.authorCastañeda-Loaiza, Viana
dc.contributor.authorPlacines, Chloé
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorPereira, Catarina
dc.contributor.authorZengin, Gokhan
dc.contributor.authorUysal, Ahmet
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorReis, Catarina Pinto
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2021-06-24T11:35:58Z
dc.date.available2021-06-24T11:35:58Z
dc.date.issued2020-02
dc.description.abstractThe halophyte species Carpobrotus edulis (L.) N.E. Br, also known as Hottentot-fig, is one of the 20 most aggressive invasive species of coastal areas worldwide. It is native to South Africa, where it is used in traditional medicine for the treatment of several diseases, including tuberculosis and acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV). Aiming at a sustainable use of its biomass as a value-added product, this work reports for the first time the in vitro antioxidant, anti-microbial, enzymatic inhibitory properties and toxicity of peel and flesh extracts of Hottentot-fig mature fruits. The extracts' chemical composition was also determined by spectrophotometric methods (total contents of phenolics: TPC; flavonoids: TFC and tannins: TTC), and by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS/MS). The peels' extracts had generally the highest TPC, TFC and TTC, especially the ethanol ones (TPC: 272.82 mg gallic acid equivalents (GAE)/g dry weight (DW), TFC: 1.58 mg quercetin equivalents (QE)/g DW and TTC: 20.3 mg catechin equivalents (CE)/g DW). The peels' extracts also had the highest diversity of compounds, mostly phenolic acids, flavonoids, and coumarins, as identified by HPLC-ESI-MS/MS. Some molecules were specific to a particular fruit part, for example, coumaric acid and uvaol in the peel, and vanillin and kaempferol-O-(rhamnosyl)hexosylhexoside in the flesh. Some compounds are here described for the first time in Hottentot-fig, such as azelaic acid and emodin. The peel's extracts had the highest anti radical activity, especially the ethanol and acetone towards 2,2-diphenyl-1-picrylhydrazyl (DPPH) (half maximal inhibitory concentration (IC50) values of 0.59 and 0.88 mg/mL, respectively), and the acetone extract against 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) (IC50 = 0.56 mg/mL). Samples had nil capacity to chelate iron, a low copper chelation potential, but a significant capacity to reduce iron, especially the ethanol (IC50 = 0.09 mg/mL) and the acetone extracts of peels (IC50 = 0.10 mg/mL) and flesh (IC50 = 0.11 mg/mL) and also the water peel's extracts (IC50 = 0.18 mg/mL). Samples had nil to low activity towards the enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), alpha-amylase and alpha-glucosidase, but displayed a strong inhibition of tyrosinase, especially the ethanol peel's extracts (29.55 mg kojic acid equivalents (KAE)/g). Samples had nil to low in vitro toxicity towards human keratinocytes. All together our results suggests possible novel biotechnological applications of Hottentot-fig fruits as sources of innovative bioactive ingredients for the food, cosmetic, agriculture and/or pharmaceutical industries.
dc.description.sponsorshipGreenVet project [ALG-01-0145-FEDER-028876]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.indcrop.2019.112005
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10400.1/16588
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre of Marine Sciences
dc.relationResearch Institute for Medicines
dc.relationUnravelling the biotechnological potential of halophyte species from the Algarve coast - HaloBiotech
dc.relationNot Available
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEnzyme inhibitors
dc.subjectSalt tolerant plants
dc.subjectHottentot-fig
dc.subjectHyperpigmentation
dc.subjectInvasive species
dc.subjectOxidative stress
dc.subject.otherAgriculture
dc.titleIf you cannot beat them, join them: exploring the fruits of the invasive species Carpobrotus edulis (L.) NE Br as a source of bioactive products
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Marine Sciences
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleUnravelling the biotechnological potential of halophyte species from the Algarve coast - HaloBiotech
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F116604%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00425%2F2017%2FCP1391%2FCT0001/PT
oaire.citation.startPage112005
oaire.citation.titleIndustrial Crops and Products
oaire.citation.volume144
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
oaire.fundingStreamCEEC IND 2017
person.familyNameCastañeda-Loaiza
person.familyNamePlacines
person.familyNameRodrigues
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.givenNameViana
person.givenNameChloé
person.givenNameMaria João
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.identifierR-004-VNG
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id2319-B2D8-AF48
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0002-8839-1389
person.identifier.orcid0000-0001-8550-5099
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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