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Antioxidant, Anti-inflammatory and Anti-hyperglycaemic Activities of Essential Oils from Thymbra capitata, Thymus albicans, Thymus caespititius, Thymus carnosus, Thymus lotocephalus and Thymus mastichina from Portugal

2016-07Journal article Restricted
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dc.contributor.authorS, Azza
dc.contributor.authorEL-GEUNDOUZ, Soukaina
dc.contributor.authorMiguel, Maria
dc.contributor.authorAntunes, Maria Dulce
dc.contributor.authorFaleiro, Maria Leonor
dc.contributor.authorCorreia, A. Isabel
dc.contributor.authorFigueiredo, A. Cristina
dc.date.accessioned2017-04-07T15:56:24Z
dc.date.available2017-04-07T15:56:24Z
dc.date.issued2016-07
dc.description.abstractThe in vitro antioxidant, anti-inflammatory, anti-hyperglycaemic, and anti-acetylcholinesterase activities of the essential oils (EOs) isolated from six Lamiaceae species (Thymbra capitata, Thymus albicans, Th. caespititius, Th. carnosus, Th. lotocephalus and Th. mastichina) grown in Portugal, were evaluated. Th. caespititius and T. capitata carvacrol/thymol-rich EOs showed the best capacity for preventing lipid peroxidation, and scavenging the 2,2 '-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and peroxyl free radicals, as well as for inhibiting lipoxygenase and alpha-amylase. However, Th. caespititius and Th. lotocephalus 1,8-cineole and linalool rich EOs were the best inhibitors of alpha-glucosidase. T. capitata, Th. lotocephalus and Th. albicans EOs were the most active for inhibiting acetylcholinesterase. Th. caespititius and Th. mastichina EOs were the main scavengers of nitric oxide (NO) radicals. The comparison between the present data with a survey of the existing literature on the in vitro biological activities of the essential oils isolated from the same species from Portuguese origin, using other methodologies, showed some differences. For instance the use of two oxidizable substrates (egg yolk and lecithin liposomes) led to distinct results mainly for those samples with relatively low activity. In addition, the EOs capacity for scavenging peroxyl radicals was also influenced by the presence of cyclodextrins, as a synergism seemed to occur between EOs and those carbohydrates.
dc.description.sponsorshipFEDER PT2020-Compete 2020
dc.identifier.issn1934-578X
dc.identifier.urihttp://hdl.handle.net/10400.1/9401
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNatural Product Incorporation
dc.relationStrategic Project - LA 23 - 2011-2012
dc.relation.isbasedonWOS:000381065900039
dc.titleAntioxidant, Anti-inflammatory and Anti-hyperglycaemic Activities of Essential Oils from Thymbra capitata, Thymus albicans, Thymus caespititius, Thymus carnosus, Thymus lotocephalus and Thymus mastichina from Portugal
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 23 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0023%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FAMB%2F50017%2F2013/PT
oaire.citation.endPage1038
oaire.citation.issue7
oaire.citation.startPage1029
oaire.citation.titleNatural Product Communications
oaire.citation.volume11
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream5876
person.familyNameAAZZA
person.familyNameEl-Guendouz
person.familyNameMiguel
person.familyNameAntunes
person.familyNameFaleiro
person.givenNameSmail
person.givenNameSoukaina
person.givenNameMaria da Graça
person.givenNameMaria Dulce
person.givenNameMaria Leonor
person.identifier1426445
person.identifierhttps://scholar.google.com/citations?user=CYBI8q8AAAAJ&hl=fr
person.identifier177556
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person.identifier.ciencia-idE416-77DF-6A97
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person.identifier.orcid0000-0002-9339-8999
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person.identifier.orcid0000-0002-8913-6136
person.identifier.orcid0000-0002-3878-6948
person.identifier.ridL-7630-2017
person.identifier.ridA-4683-2012
person.identifier.scopus-author-id51664684500
person.identifier.scopus-author-id57190122389
person.identifier.scopus-author-id35562054500
person.identifier.scopus-author-id7102645075
person.identifier.scopus-author-id6507927018
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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