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Sustainable carbon dots loaded into carboxymethylcellulose based hydrogels for uterine cancer bioimaging

2024-11-22Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorRodrigues, Jordane S.
dc.contributor.authorBrandão, Pedro
dc.contributor.authorDuarte, Sofia O. D.
dc.contributor.authorSilveira, Izabela Boueri da
dc.contributor.authorLeite, Maria de Fátima
dc.contributor.authorGonçalves, Max P.
dc.contributor.authorBorsagli, Fernanda G. L. Medeiros
dc.contributor.authorFonte, Pedro
dc.date.accessioned2026-01-20T11:38:06Z
dc.date.available2026-01-20T11:38:06Z
dc.date.issued2024-11-22
dc.description.abstractAbstract: Background/Objectives: The development of innovative materials for disease diagnostics and therapeutics is a fast-growing area of scientific research. In this work, we report the development of innovative hydrogels incorporating carbon dots (Cdots) for bioimaging purposes. Methods: The Cdots were prepared using a sustainable and low-cost process, starting with an underused fiber from the Brazilian semiarid region. Spectroscopy analysis (Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, UV-visible spectroscopy), X-ray diffraction, photoluminescence, zeta potential, scanning electron microscopy, and transmission electron microscopy were used to characterize these hydrogels. In addition, biocompatibility using the resazurin assay and cellular uptake by confocal microscopy were evaluated. Results: Our results showed that the Cdots changed the structure and crystallinity of hydrogels, mainly due to heat treatment. In addition, hydrogels’ chemical groups suffer red and blue shifts following the Cdots incorporation. Moreover, the Cdots were homogeneously incorporated into the hydrogel matrix. Importantly, the cytotoxicity levels were maintained above 90% (p < 0.01), and cellular uptake studies using HeLa cells demonstrated intracellular fluorescence of both the Cdots and hydrogels after incubation. Additionally, the concentration of Cdots within hydrogels significantly affected fluorescence intensity, even compared with pure Cdots. Conclusions: These results showcase the potential for these hydrogels to be further developed as biomarkers and therapeutic biomaterials for women’s health.eng
dc.identifier.doi10.3390/pharmaceutics16121500
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.1/28150
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Health and Bioeconomy
dc.relationEgas Moniz Interdisciplinary Research Center
dc.relation.ispartofPharmaceutics
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCarbon dots
dc.subjectUterine cancer
dc.subjectHydrogels
dc.subjectBioimaging
dc.subjectCircular economy
dc.subjectBiomaterials
dc.titleSustainable carbon dots loaded into carboxymethylcellulose based hydrogels for uterine cancer bioimagingeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleEgas Moniz Interdisciplinary Research Center
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04585%2F2020/PT
oaire.citation.issue12
oaire.citation.startPage1500
oaire.citation.titlePharmaceutics
oaire.citation.volume16
oaire.fundingStream6817 - DCRRNI ID
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oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFonte
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person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0002-1115-9282
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