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Immune status and hepatic antioxidant capacity of Gilthead Seabream Sparus aurata juveniles fed yeast and microalga derived β-glucans

2021-12Journal article Open access
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dc.contributor.authorReis, Bruno
dc.contributor.authorGonçalves, Ana Teresa
dc.contributor.authorSantos, Paulo
dc.contributor.authorSardinha, Manuel
dc.contributor.authorConceição, Luís E. C.
dc.contributor.authorSerradeiro, Renata
dc.contributor.authorPérez-Sánchez, Jaume
dc.contributor.authorCalduch-Giner, Josep
dc.contributor.authorSchmid-Staiger, Ulrike
dc.contributor.authorFrick, Konstantin
dc.contributor.authorDias, Jorge
dc.contributor.authorCostas, Benjamín
dc.date.accessioned2022-01-18T14:38:40Z
dc.date.available2022-01-18T14:38:40Z
dc.date.issued2021-12
dc.description.abstractThis work aimed to evaluate the effects of dietary supplementation with β-glucans extracted from yeast (Saccharomyces cerevisiae) and microalga (Phaeodactylum tricornutum) on gene expression, oxidative stress biomarkers and plasma immune parameters in gilthead seabream (Sparus aurata) juveniles. A practical commercial diet was used as the control (CTRL), and three others based on CTRL were further supplemented with different β-glucan extracts. One was derived from S. cerevisiae (diet MG) and two different extracts of 21% and 37% P. tricornutum-derived β-glucans (defined as Phaeo21 and Phaeo37), to give a final 0.06% β-glucan dietary concentration. Quadruplicate groups of 95 gilthead seabream (initial body weight: 4.1 ± 0.1 g) were fed to satiation three times a day for 8 weeks in a pulse-feeding regimen, with experimental diets intercalated with the CTRL dietary treatment every 2 weeks. After 8 weeks of feeding, all groups showed equal growth performance and no changes were found in plasma innate immune status. Nonetheless, fish groups fed β-glucans supplemented diets showed an improved anti-oxidant status compared to those fed CTRL at both sampling points (i.e., 2 and 8 weeks). The intestinal gene expression analysis highlighted the immunomodulatory role of Phaeo37 diet after 8 weeks, inducing an immune tolerance effect in gilthead seabream intestine, and a general down-regulation of immune-related gene expression. In conclusion, the results suggest that the dietary pulse administration of a P. tricornutum 37% enriched-β-glucans extract might be used as a counter-measure in a context of gut inflammation, due to its immune-tolerant and anti-oxidative effects.pt_PT
dc.description.sponsorshipNORTE-01-0145-FEDER-000040
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/md19120653pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.1/17493
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMicroalgae As a Green source for Nutritional Ingredients for Food/Feed and Ingredients for Cosmetics by cost-Effective New Technologies
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationImproving health and grwth in gilthead seabream Sparus aurata through fortified nutrition: discovering new nutraceuticals from marine bio-refineries
dc.relationUnravelling the functional importance of amino acids in the fish neuroendocrine-immune network
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSaccharomyces cerevisiaept_PT
dc.subjectPhaeodactylum tricornutumpt_PT
dc.subjectSparus auratapt_PT
dc.subjectβ-glucans;pt_PT
dc.subjectPulse feedingpt_PT
dc.subjectImmune tolerancept_PT
dc.titleImmune status and hepatic antioxidant capacity of Gilthead Seabream Sparus aurata juveniles fed yeast and microalga derived β-glucanspt_PT
dc.title.alternativeStatus imunológico e capacidade antioxidante hepática de Gilthead Seabream Sparus aurata juveniles fed leveduras e microalga derivadas de Beta-glucanospt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMicroalgae As a Green source for Nutritional Ingredients for Food/Feed and Ingredients for Cosmetics by cost-Effective New Technologies
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleImproving health and grwth in gilthead seabream Sparus aurata through fortified nutrition: discovering new nutraceuticals from marine bio-refineries
oaire.awardTitleUnravelling the functional importance of amino acids in the fish neuroendocrine-immune network
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/745754/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/PD%2FBDE%2F129262%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/IF%2F00197%2F2015%2FCP1277%2FCT0001/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage653pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume19pt_PT
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFachadas Gato Coelho Gonçalves
person.givenNameAna Teresa
person.identifier.ciencia-id9F1F-939B-B01A
person.identifier.orcid0000-0002-5443-7182
person.identifier.scopus-author-id56308820700
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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