Synthesis and structure of 2-substituted pyrene-derived scaffolds

Cabral, Lília; Henriques, Marta Sofia; Paixão, José António; Lurdes S. Cristiano, M.

http://hdl.handle.net/10400.1/12923

Utilize este identificador para referenciar este registo.

Nome:	Descrição:	Tamanho:	Formato:
1-s2.0-S0040403917313473-main.pdf		755.36 KB	Adobe PDF	Ver/Abrir

Contacte-nos

Autores

Cabral, Lília

Henriques, Marta Sofia

Paixão, José António

Lurdes S. Cristiano, M.

Resumo(s)

Pyrenes bear a propensity to form fluorescent excimers, and thus this chromophore is often found in sensors and fluorescent probes. 2-FunctionaIized pyrenes are of particular interest, however the preparation of these scaffolds is not trivial, involving synthetic routes that require 4,5,9,10-tetrahydropyrene as a key intermediate. Herein, the development and optimization of routes for the synthesis of 2-functionalized pyrene-derived building blocks, with potential to be used as tags in the preparation of fluorescent probes, is described. Additionally, the crystal structures of ethyl 4,5,9,10-tetrahydro-2-pyrene-5-oxopentanoate and 2-acetyl-4,5,9,10-tetrahydropyrene revealed distinct conformations of the saturated tetrahydropyrene rings. (C) 2017 Elsevier Ltd. All rights reserved.