Repository logo
 
Publication

A PTH/PTHrP receptor antagonist blocks the hypercalcemic response to estradiol-17b

2007-05-30Journal article Open Access
Simple item page
dc.contributor.authorFuentes, J.
dc.contributor.authorGuerreiro, P. M.
dc.contributor.authorModesto, Teresa
dc.contributor.authorRotllant, J.
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorPower, Deborah
dc.date.accessioned2012-07-25T13:20:42Z
dc.date.available2012-07-25T13:20:42Z
dc.date.issued2007-05-30
dc.description.abstractEstradiol (E2) increases circulating calcium and phosphate levels in fish, thus acting as a hypercalcemic and hyperphosphatemic factor during periods of high calcium requirements, such as during vitellogenesis. Since parathyroid hormone (PTH)-related protein (PTHrP) has been shown to be calciotropic in fish, we hypothesized that the two hormones could be mediating the same process. Sea bream (Sparus auratus) juveniles receiving a single intraperitoneal injection of piscine PTHrP(1-34) showed an elevation in calcium plasma levels within 24 h. In contrast, injections of the PTH/PTHrP receptor antagonist PTHrP(7-34) decreased circulating levels of calcium in the same period. Intraperitoneal implants of estradiol-17 (E2; 10 g/g) evoked significant increases of circulating plasma levels of calcium and phosphorus and a sustained increases of circulating plasma levels of PTHrP. However, a combined treatment of E2 and PTHrP(7-34) evoked a markedly lower calcium response compared with E2 alone. We conclude that PTHrP or a related peptide that binds the PTH/PTHrP receptor mediates, at least in part, the hypercalcemic effect of E2 in calcium and phosphate balance in fish.por
dc.identifier.issn0363-6119
dc.identifier.otherAUT: ACA00258; DPO00386; TMO00411;
dc.identifier.urihttp://hdl.handle.net/10400.1/1548
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Physiological Societypor
dc.relationPhysiology of PTHrP in fish, relevance to calcium balance of an unique hypercalcemic factor
dc.relation.publisherversionhttp://ajpregu.physiology.org/content/293/2/R956.full.pdf+htmlpor
dc.subjectFishpor
dc.subjectCalciumpor
dc.subjectPhosphatepor
dc.titleA PTH/PTHrP receptor antagonist blocks the hypercalcemic response to estradiol-17bpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePhysiology of PTHrP in fish, relevance to calcium balance of an unique hypercalcemic factor
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCTI%2FCVT%2F48946%2F2002/PT
oaire.citation.endPageR960por
oaire.citation.issue293por
oaire.citation.startPageR956por
oaire.citation.titleAmerican Journal of Physiology - Regulatory, Integrative and Comparative Physiologypor
oaire.fundingStreamPOCI
person.familyNameFuentes
person.familyNameGuerreiro da Costa Guerreiro
person.familyNameModesto
person.familyNameCanario
person.familyNamePower
person.givenNameJuan
person.givenNamePedro Miguel
person.givenNameTeresa
person.givenNameAdelino
person.givenNameDeborah Mary
person.identifier392998
person.identifierA-2539-2009
person.identifier143624
person.identifier.ciencia-id421B-E196-2C33
person.identifier.ciencia-id5C13-965D-3148
person.identifier.ciencia-idBD1C-7610-B888
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0003-0430-8734
person.identifier.orcid0000-0001-5371-7919
person.identifier.orcid0000-0002-2691-4906
person.identifier.orcid0000-0002-6244-6468
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201832526
person.identifier.scopus-author-id6603372075
person.identifier.scopus-author-id56568523700
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationd354b937-b18c-4ca5-a843-04a04269d60f
relation.isAuthorOfPublicationd0a8a148-98e7-4899-8fb0-0b8afa91e4a4
relation.isAuthorOfPublicationfc9019ec-88bd-4fb1-a4b8-dd5eed1fd284
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscovery5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isProjectOfPublicationc309d350-f364-4356-b893-7af20e0a75d7
relation.isProjectOfPublication.latestForDiscoveryc309d350-f364-4356-b893-7af20e0a75d7

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Fuentes et al_2007_Am J Physiol Regul Integr Comp Physiol.pdf
Size:
95.47 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCT2-Artigos (em revistas ou actas indexadas)