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Development of carboxymethyl cellulose-chitosan hybrid micro- and macroparticles for encapsulation of probiotic bacteria

2017-11Journal article Restricted access
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dc.contributor.authorSingh, P.
dc.contributor.authorMedronho, B.
dc.contributor.authorAlves, L.
dc.contributor.authorda Silva, G. J.
dc.contributor.authorMiguel, M. G.
dc.contributor.authorLindman, B.
dc.date.accessioned2019-11-20T15:07:14Z
dc.date.available2019-11-20T15:07:14Z
dc.date.issued2017-11
dc.description.abstractNovel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2 mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5 tim) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes. On the other hand, the physical systems are pH sensitive presenting a remarkable swelling at pH 7.4, while little swelling is observed at pH 2.4. Furthermore, model probiotic bacteria (Lactobacillus rhamnosus GG) was for the first time successfully encapsulated in the CMC-Cht based particles with acceptable viability count. Overall, the systems developed are highly promising for probiotic encapsulation and potential delivery in the intestinal tract with the purpose of modulating gut microbiota and improving human health. (C) 2017 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT) [PTDC/AGR-TEC/4814/2014, IF/01005/2014]
dc.identifier.doi10.1016/j.carbpol.2017.06.119
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.urihttp://hdl.handle.net/10400.1/12940
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier Sci Ltd
dc.relationBiopolymer Based FOOd Delivery Systems
dc.subjectOppositely charged polyelectrolytes
dc.subjectCross-linking
dc.subjectLactobacillus-acidophilus
dc.subjectSugarcane bagasse
dc.subjectPolyion-complex
dc.subjectHydrogels
dc.subjectGenipin
dc.subjectDelivery
dc.subjectMicroencapsulation
dc.subjectAlginate
dc.titleDevelopment of carboxymethyl cellulose-chitosan hybrid micro- and macroparticles for encapsulation of probiotic bacteria
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiopolymer Based FOOd Delivery Systems
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/606713/EU
oaire.citation.endPage95
oaire.citation.startPage87
oaire.citation.titleCarbohydrate Polymers
oaire.citation.volume175
oaire.fundingStreamFP7
person.familyNameMedronho
person.givenNameBruno
person.identifier.ciencia-id6918-9AB3-8D22
person.identifier.orcid0000-0003-0972-1739
person.identifier.ridP-5927-2014
person.identifier.scopus-author-id9940656700
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication4c03571a-93da-4504-8acf-c74326449852
relation.isAuthorOfPublication.latestForDiscovery4c03571a-93da-4504-8acf-c74326449852
relation.isProjectOfPublicationdd5e86b3-11f1-490e-a97b-eba98a490296
relation.isProjectOfPublication.latestForDiscoverydd5e86b3-11f1-490e-a97b-eba98a490296

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