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Synergistic effect of aloe vera hydrogels with imatinib for pH-responsive drug release in breast cancer treatment

2025-10-09Journal article Restricted access
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dc.contributor.authorKhan, Aroob Hasan
dc.contributor.authorShehzad, Adeeb
dc.contributor.authorPirela, Paola
dc.contributor.authorAtalaia, Mariana
dc.contributor.authorRuivinho, Beatriz Lourenço
dc.contributor.authorRashan, Luay
dc.contributor.authorMiran, Waheed
dc.contributor.authorDuarte, Sofia O. D.
dc.contributor.authorFonte, Pedro
dc.date.accessioned2025-10-27T13:58:59Z
dc.date.available2025-10-27T13:58:59Z
dc.date.issued2025-10-09
dc.description.abstractImatinib (IM) efficacy as a cancer drug is limited by pharmacokinetic drug resistance developed during systemic circulation before reaching the target site.Hydrogels have attracted attention because of their characteristic physiochemical and biochemical properties, flexibility, and the ability to release drugs directly at target sites causing cancer mitigation. The current study aims at developing Aloe Vera (AV) hydrogels for the efficient and targeted delivery of IM into cancer cells and studying its synergistic effect. Incorporating Aloe Vera into the previously studied Sodium Alginate (SA)/PolyVinyl Alcohol (PVA) hydrogels and loading with IM is expected to reach a pH-responsive release efficiency, enhanced biochemical properties and increased cancer cell cytotoxicity. The hydrogels, SA/PVA and SA/PVA/AV were characterized (FT-IR, SEM) and investigated for their physiochemical properties. The presence of AV and IM were confirmed by the increase in the intensity of band from 3000 to 3500 cm-1, while an increase in the pore size was observed upon the loading of IM. The final formulation, SA/PVA/AV hydrogels displayed increased pore size which leveraged their swelling, degradation, encapsulation, and release properties by 400%, 100%, 56%, and 94%, respectively. The in vitro analysis on breast cancer cells showed that the SA/PVA/AV hydrogels loaded with IM worked synergistically to significantly reduce the cancer cell viability to 40%, surpassing the efficacy of the SA/PVA/AV hydrogel and IM treatments alone. This study highlights the promising potential for the use of AV in the development of a drug delivery system (DDS) for targeting and improving therapeutic outcomes in cancer treatment.eng
dc.identifier.doi10.1007/s13346-025-01981-y
dc.identifier.eissn2190-3948
dc.identifier.issn2190-393X
dc.identifier.urihttp://hdl.handle.net/10400.1/27854
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relationCentre of Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationInstitute for Health and Bioeconomy
dc.relationCentre of Marine Sciences
dc.relation.ispartofDrug Delivery and Translational Research
dc.rights.uriN/A
dc.subjectAloevera
dc.subjectPH-responsive
dc.subjectCancer
dc.subjectImatinib
dc.subjectHydrogels
dc.subjectAntioxidant assay
dc.titleSynergistic effect of aloe vera hydrogels with imatinib for pH-responsive drug release in breast cancer treatmenteng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleCentre of Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2019/PT
oaire.citation.titleDrug Delivery and Translational Research
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRuivinho
person.familyNameFonte
person.givenNameBeatriz Lourenço
person.givenNamePedro
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0009-0002-7615-8122
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id55146900200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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