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Stanniocalcin-1 protein expression profile and mechanisms in proliferation and cell death pathways in prostate cancer

2020-02Journal article Restricted access
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dc.contributor.authorCosta, Bruna Pasqualotto
dc.contributor.authorSchein, Vanessa
dc.contributor.authorZhao, R.
dc.contributor.authorSantos, Andressa Schneiders
dc.contributor.authorKliemann, Lucia Maria
dc.contributor.authorNunes, Fernanda Bordignon
dc.contributor.authorCardoso, João CR
dc.contributor.authorC. Félix, Rute
dc.contributor.authorCanario, Adelino
dc.contributor.authorBrum, Ilma Simoni
dc.contributor.authorBranchini, Gisele
dc.date.accessioned2020-09-01T13:18:01Z
dc.date.available2021-02-01T01:30:16Z
dc.date.issued2020-02
dc.description.abstractProstate cancer (PCa) is one of the most prevalent male tumours. Stanniocalcin-1 (STC1) is a glycoprotein and, although the role of STC1 in human cancer is poorly understood, it is suggested to be involved in the development and progression of different neoplasms. This study investigated the protein expression profile of STC1 in PCa and benign prostatic hyperplasia (BPH) samples and STC1 signalling during cell proliferation and cell death in vitro using cell lines. We found higher levels of STC1 in PCa when compared to BPH tissue and that STC1 inhibited forskolin stimulation of cAMP in PC-3 cells. A monoclonal antibody against STC1 was effective in reducing cell proliferation, in promoting cell cycle arrest, and in increasing apoptosis in the same cells. Since STC1 acts as a regulator of prostatic tissue signalling, we suggest that this protein is a novel candidate biomarker for prostate tumour clinical progression and a potential therapeutic target.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.mce.2019.110659pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.1/14664
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectProstatic neoplasmpt_PT
dc.subjectProstate cancerpt_PT
dc.subjectStanniocalcin-1pt_PT
dc.subjectTumour developmentpt_PT
dc.subjectGleason scorept_PT
dc.titleStanniocalcin-1 protein expression profile and mechanisms in proliferation and cell death pathways in prostate cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage110659pt_PT
oaire.citation.titleMolecular and Cellular Endocrinologypt_PT
oaire.citation.volume502pt_PT
person.familyNameCardoso
person.familyNameFélix
person.familyNameCanario
person.givenNameJoão
person.givenNameRute
person.givenNameAdelino
person.identifier14332
person.identifier143624
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-idFB1A-1325-8E25
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0002-4144-3452
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridM-4151-2013
person.identifier.ridM-6164-2013
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id56006773000
person.identifier.scopus-author-id56568523700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication9b5e820d-e41f-4c28-8832-823658d29ae9
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscovery5f6e51ee-9113-469e-8b9e-f30f2d452521

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