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PXR variants and artemisinin use in vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin
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Orientador(es)
Resumo(s)
Artemisinins induce drug metabolism through the activation of the pregnane X receptor (PXR) in vitro. Here, we report the re-sequencing and genotyping of PXR variants in 75 Vietnamese individuals previously characterized for CYP3A enzyme activity after artemisinin exposure. We identified a total of 31 PXR variants, including 5 novel single nucleotide polymorphisms (SNPs), and we identified significantly different allele frequencies relative to other ethnic groups. A trend of significance was observed between the level of CYP3A4 induction by artemisinin and two PXR variants, the 8118C -> T (Y328Y) and 10719A -> G variants.
Descrição
Palavras-chave
Pregnane-X-receptor Single-nucleotide polymorphisms Constitutive-androstane-receptor Inflammatory-bowel-disease Falciparum-malaria Gene Association Pharmacokinetics Pharmacogenetics Cytochrome-P450
Contexto Educativo
Citação
Editora
American Society for Microbiology