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PXR variants and artemisinin use in vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin

2012-04Journal article Open access
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dc.contributor.authorPiedade, Rita
dc.contributor.authorSchaeffeler, Elke
dc.contributor.authorWinter, Stefan
dc.contributor.authorAsimus, Sara
dc.contributor.authorSchwab, Matthias
dc.contributor.authorAshton, Michael
dc.contributor.authorBurk, Oliver
dc.contributor.authorGil, José Pedro
dc.date.accessioned2018-12-07T14:52:31Z
dc.date.available2018-12-07T14:52:31Z
dc.date.issued2012-04
dc.description.abstractArtemisinins induce drug metabolism through the activation of the pregnane X receptor (PXR) in vitro. Here, we report the re-sequencing and genotyping of PXR variants in 75 Vietnamese individuals previously characterized for CYP3A enzyme activity after artemisinin exposure. We identified a total of 31 PXR variants, including 5 novel single nucleotide polymorphisms (SNPs), and we identified significantly different allele frequencies relative to other ethnic groups. A trend of significance was observed between the level of CYP3A4 induction by artemisinin and two PXR variants, the 8118C -> T (Y328Y) and 10719A -> G variants.
dc.description.sponsorshipStyrelsen for Internationellt Utvecklingssamarbete (SIDA), Sweden [SWE-2009-165]; Karolinska Institutet Fond; ICEEPHA (Tubingen-Stuttgart, Germany) [2009-10-0-0]; Federal Ministry for Education and Research (BMBF) (Berlin, Germany) [03 IS 2061C]; DFG [KE 1629/1-1]; Robert Bosch Foundation, Stuttgart, Germany; Fundacao para a Ciencia e Tecnologia, Ministerio da Ciencia e Ensino Superior, Portugal; European and Developing Countries Clinical Trials Partnership (EDCTP)
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1128/AAC.06009-11
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/10400.1/11104
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Society for Microbiology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPregnane-X-receptor
dc.subjectSingle-nucleotide polymorphisms
dc.subjectConstitutive-androstane-receptor
dc.subjectInflammatory-bowel-disease
dc.subjectFalciparum-malaria
dc.subjectGene
dc.subjectAssociation
dc.subjectPharmacokinetics
dc.subjectPharmacogenetics
dc.subjectCytochrome-P450
dc.titlePXR variants and artemisinin use in vietnamese subjects: frequency distribution and impact on the interindividual variability of CYP3A induction by artemisinin
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2157
oaire.citation.issue4
oaire.citation.startPage2153
oaire.citation.titleAntimicrobial Agents and Chemotherapy
oaire.citation.volume56
person.familyNameGil
person.givenNameJosé Pedro
person.identifier.ciencia-idD01A-B30E-BCD5
person.identifier.orcid0000-0002-6107-9379
person.identifier.scopus-author-id7201625436
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationcb728715-0e4c-4ae5-9e21-b6a8f35a8313
relation.isAuthorOfPublication.latestForDiscoverycb728715-0e4c-4ae5-9e21-b6a8f35a8313

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