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Advancing glioblastoma research with innovative brain organoid-based models

2025-02-16Journal article Open access
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dc.contributor.authorDias Correia, Cátia
dc.contributor.authorCalado, Sofia
dc.contributor.authorMatos, Alexandra
dc.contributor.authorOleiro Esteves, Filipa Alexandra
dc.contributor.authorDe Sousa-Coelho, Ana Luísa
dc.contributor.authorCampinho, Marco António
dc.contributor.authorTeotónio Fernandes, Mónica Alexandra
dc.date.accessioned2025-03-13T14:15:07Z
dc.date.available2025-03-13T14:15:07Z
dc.date.issued2025-02-16
dc.description.abstractGlioblastoma (GBM) is a relatively rare but highly aggressive form of brain cancer characterized by rapid growth, invasiveness, and resistance to standard therapies. Despite significant progress in understanding its molecular and cellular mechanisms, GBM remains one of the most challenging cancers to treat due to its high heterogeneity and complex tumor microenvironment. To address these obstacles, researchers have employed a range of models, including in vitro cell cultures and in vivo animal models, but these often fail to replicate the complexity of GBM. As a result, there has been a growing focus on refining these models by incorporating human-origin cells, along with advanced genetic techniques and stem cell-based bioengineering approaches. In this context, a variety of GBM models based on brain organoids were developed and confirmed to be clinically relevant and are contributing to the advancement of GBM research at the preclinical level. This review explores the preparation and use of brain organoid-based models to deepen our understanding of GBM biology and to explore novel therapeutic approaches. These innovative models hold significant promise for improving our ability to study this deadly cancer and for advancing the development of more effective treatments.eng
dc.description.sponsorship2024.01695.BD
dc.identifier.doi10.3390/cells14040292
dc.identifier.issn2073-4409
dc.identifier.urihttp://hdl.handle.net/10400.1/26908
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationExploring CITED2 role in glioblastoma stem cell biology
dc.relation2024.01695.BD
dc.relation.ispartofCells
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGlioblastoma
dc.subjectBrain organoids
dc.subjectDisease models
dc.subjectDrug discovery
dc.subjectHuman stem cells
dc.subjectTumor heterogeneity
dc.subjectInvasion
dc.subjectMicroenvironment
dc.titleAdvancing glioblastoma research with innovative brain organoid-based modelseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleExploring CITED2 role in glioblastoma stem cell biology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.09209.PTDC/PT
oaire.citation.issue4
oaire.citation.startPage292
oaire.citation.titleCells
oaire.citation.volume14
oaire.fundingStream3599-PPCDT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDias Correia
person.familyNameCalado
person.familyNameMatos
person.familyNameOleiro Esteves
person.familyNameDe Sousa-Coelho
person.familyNameCampinho
person.familyNameTeotónio Fernandes
person.givenNameCátia
person.givenNameSofia
person.givenNameAlexandra
person.givenNameFilipa Alexandra
person.givenNameAna Luísa
person.givenNameMarco António
person.givenNameMónica Alexandra
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person.identifier.orcid0000-0002-5238-0506
person.identifier.orcid0000-0002-1206-1367
person.identifier.ridK-2202-2016
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person.identifier.scopus-author-id56426215600
person.identifier.scopus-author-id8938999600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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