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Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection

2014Journal article Open access
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dc.contributor.authorNunes, Ricardo
dc.contributor.authorRodrigues, Susana
dc.contributor.authorPasko, Pawel
dc.contributor.authorTyszka-Czochara, Malgorzata
dc.contributor.authorGrenha, Ana
dc.contributor.authorCarvalho, Isabel Saraiva de
dc.date.accessioned2013-12-04T14:12:21Z
dc.date.available2013-12-04T14:12:21Z
dc.date.issued2014
dc.description.abstractPlants from the genus Erica are used in many countries to treat several ailments. In this work we intend to evaluate the potential in vivo benefits of Erica australis L. by testing in vitro the effect induced by the plant extract when in contact with BJ fibroblasts (3 and 9 hours) and Caco-2 cells (3, 6 and 24 hours). Effects on five pathogenic microorganisms(Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus and Listeria monocytogenes) were also determined. It was found that the extracts enhanced fibroblast proliferation (maximum of 484% of control at 6 hour exposure) while Caco-2 cells viability was reduced in a concentration and time dependent manner (minimum of 22.3% of control at 24 hour exposure). Antimicrobial effects were also detected, with differences registered among the plant parts and solvent used, with the lowest minimum concentration for diffusion inhibition (MCDI) of 1 mg/mL. Results obtained with the fibroblasts and bacteria strongly show that this plant has potential to be used in wound healing as a stimulant of fibroblast growth and disinfection, as well as an antibiotic. Results obtained with Caco-2 cells indicate this plant also has some potential for and application as anticancer agent.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.indcrop.2013.10.015
dc.identifier.issn0926-6690
dc.identifier.otherAUT: AMG02212; ICA01121;
dc.identifier.urihttp://hdl.handle.net/10400.1/3220
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0926669013005670por
dc.subjectErica australis Lpor
dc.subjectFibroblastspor
dc.subjectCaco-2por
dc.subjectAntiproliferative effectpor
dc.subjectWound healing stimulantpor
dc.subjectAntibacterialpor
dc.titleEffect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infectionpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage104por
oaire.citation.startPage99por
oaire.citation.titleIndustrial Crops and Productspor
oaire.citation.volume52por
person.familyNameNunes
person.familyNameRodrigues
person.familyNameGrenha
person.familyNameSaraiva de Carvalho
person.givenNameRicardo
person.givenNameSusana
person.givenNameAna
person.givenNameIsabel Maria Marques
person.identifier.ciencia-id9D1A-6537-0383
person.identifier.ciencia-id091C-0D58-7225
person.identifier.ciencia-id591A-3777-B036
person.identifier.orcid0000-0002-0500-6300
person.identifier.orcid0000-0002-0329-4265
person.identifier.orcid0000-0002-2136-1396
person.identifier.orcid0000-0001-8057-3404
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id55125292100
person.identifier.scopus-author-id8607930100
person.identifier.scopus-author-id35995183800
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublicationf7e806c8-708d-4caf-9b95-cfe9f3b06e8e
relation.isAuthorOfPublication1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d
relation.isAuthorOfPublicationaf26e659-578b-4e5f-a649-384cd5e4f8e3
relation.isAuthorOfPublication.latestForDiscovery1bd4d8f1-40e5-45af-b1e8-4b8e73a6a70d

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