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Theoretical approaches used in the modelling of reversible and irreversible mitochondrial swelling in vitro

2022Journal article Restricted access
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dc.contributor.authorKhmelinskii, Igor
dc.contributor.authorMakarov, Vladimir I.
dc.date.accessioned2023-05-10T09:51:52Z
dc.date.available2023-05-10T09:51:52Z
dc.date.issued2022
dc.description.abstractExisting theoretical approaches were considered that allow modelling of mitochondrial swelling (MS) dynamics. Simple phenomenological kinetic models were reviewed. Simple and extended biophysical and bioenergetic models that ignore mechanical properties of inner mitochondrial membrane (IMM), and similar models that include these mechanical properties were also reviewed. Limitations of these models we considered, as regards correct modelling of MS dynamics. It was found that simple phenomenological kinetic models have significant limitations, due to dependence of the kinetic parameter values estimated by fitting of the experimental data on the experimental conditions. Additionally, such simple models provide no understanding of the detailed mechanisms behind the MS dynamics, nor of the dynamics of various system parameters during MS. Thus, biophysical and bioenergetic models ignoring IMM mechanical properties can't be used to model the transition between reversible and irreversible MS. However, simple and extended biophysical models that include IMM mechanical properties allow modelling the transition to irreversible swelling. These latter models are still limited due to significantly simplified description of biochemistry, compared to those of bioenergetic models. Finally, a strategy of model development is proposed, towards correct interpretation of the mitochondrial life cycle, including the effects of MS dynamics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.pbiomolbio.2022.04.004pt_PT
dc.identifier.issn0079-6107
dc.identifier.urihttp://hdl.handle.net/10400.1/19540
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectMitochondrionpt_PT
dc.subjectReversible swellingpt_PT
dc.subjectIrreversible swellingpt_PT
dc.subjectMitochondrial membrane mechanical propertiespt_PT
dc.subjectMitochondrial membrane bending stresspt_PT
dc.subjectMitochondrial membrane stretching stresspt_PT
dc.titleTheoretical approaches used in the modelling of reversible and irreversible mitochondrial swelling in vitropt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage23pt_PT
oaire.citation.startPage15pt_PT
oaire.citation.titleProgress in Biophysics and Molecular Biologypt_PT
oaire.citation.volume172pt_PT
person.familyNameKhmelinskii
person.givenNameIgor
person.identifier0000000420541031
person.identifier.ciencia-id0D1A-CB6C-6316
person.identifier.orcid0000-0002-6116-184X
person.identifier.ridC-9587-2011
person.identifier.scopus-author-id6701444934
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfcb9f09f-2e99-41fb-8c08-7e1acbc65076
relation.isAuthorOfPublication.latestForDiscoveryfcb9f09f-2e99-41fb-8c08-7e1acbc65076

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