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An insight on lipid nanoparticles for therapeutic proteins delivery

2022Journal article Open Access
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dc.contributor.authorViegas, Cláudia
dc.contributor.authorSeck, Fatumata
dc.contributor.authorFonte, Pedro
dc.date.accessioned2023-02-08T10:38:32Z
dc.date.available2023-02-08T10:38:32Z
dc.date.issued2022
dc.description.abstractTherapeutic proteins are well-tolerated bioactive compounds used in different therapies, due to its high speci-ficity and biopotency. Nevertheless, they may also present some physicochemical instability, leading to loss of bioactivity hampering treatments. This can be avoided by its loading into lipid nanoparticles, which are biocompatible and biodegradable carriers. The use of lipids nanoparticles to deliver therapeutic proteins over-comes different challenges, allowing its administration by all delivery routes. Thus, therapeutic proteins may be loaded into liposomes, the first developed lipid-based nanocarriers composed of phospholipid bilayers, solid lipid nanoparticles composed of a solid lipid matrix, or nanostructured lipid carriers made of a blend of liquid and solid lipid as matrix. The latter are currently marking the trend in lipid nanocarriers due to its high loading capacity, good stability upon storage and better sustained release pattern. Production methods must focus both on attaining the desired nanocarrier features, and maintenance of therapeutic proteins structure and bioactivity. This review aims to make an insight overview on the application of lipid nanoparticles to deliver therapeutic proteins, showing its potential in different therapies. A special focus is given to the production techniques to obtain therapeutic proteins-loaded lipid nanoparticles.pt_PT
dc.description.sponsorshipLA/P/0101/2020
dc.description.sponsorshipLA/P/0140/2020
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jddst.2022.103839pt_PT
dc.identifier.issn1773-2247
dc.identifier.urihttp://hdl.handle.net/10400.1/19015
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI-01-0145-FEDER-032610-PTDC/MEC-DER/32610/2017pt_PT
dc.relationAntibody encapsulation into polymer nanoparticles as a promising strategy for lung cancer treatment
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDelivery systempt_PT
dc.subjectEncapsulationpt_PT
dc.subjectLiposomept_PT
dc.subjectNanostructured lipid carrierpt_PT
dc.subjectSolid lipid nanoparticlept_PT
dc.subjectTherapeutic proteinpt_PT
dc.titleAn insight on lipid nanoparticles for therapeutic proteins deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAntibody encapsulation into polymer nanoparticles as a promising strategy for lung cancer treatment
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2020.08839.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT
oaire.citation.startPage103839pt_PT
oaire.citation.titleJournal of Drug Delivery Science and Technologypt_PT
oaire.citation.volume77pt_PT
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMestre Viegas
person.familyNameFonte
person.givenNameCláudia Sofia
person.givenNamePedro
person.identifier.ciencia-idBC13-CBFD-ECA6
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0001-6668-2778
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id55146900200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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