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Divergence and gene flow history at two large chromosomal inversions underlying ecotype differentiation in the longā€snouted seahorse

2024Journal article Open Access
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dc.contributor.authorMeyer, Laura
dc.contributor.authorBarry, Pierre
dc.contributor.authorRiquet, Florentine
dc.contributor.authorFoote, Andrew
dc.contributor.authorDer Sarkissian, Clio
dc.contributor.authorCunha, Regina L.
dc.contributor.authorArbiol, Christine
dc.contributor.authorCerqueira, FrƩdƩrique
dc.contributor.authorDesmarais, Erick
dc.contributor.authorBordes, AnaĆÆs
dc.contributor.authorBierne, Nicolas
dc.contributor.authorGuinand, Bruno
dc.contributor.authorGagnaire, Pierreā€Alexandre
dc.date.accessioned2024-02-19T13:30:21Z
dc.date.available2024-02-19T13:30:21Z
dc.date.issued2024
dc.description.abstractChromosomal inversions can play an important role in divergence and reproductive isolation by building and maintaining distinct allelic combinations between evolutionary lineages. Alternatively, they can take the form of balanced polymorphisms that segregate within populations until one arrangement becomes fixed. Many questions remain about how inversion polymorphisms arise, how they are maintained over the long term, and ultimately, whether and how they contribute to speciation. The long-snouted seahorse (Hippocampus guttulatus) is genetically subdivided into geographic lineages and marine-lagoon ecotypes, with shared structural variation underlying lineage and ecotype divergence. Here, we aim to characterize structural variants and to reconstruct their history and suspected role in ecotype formation. We generated a near chromosome-level genome assembly and described genome-wide patterns of diversity and divergence through the analysis of 112 whole-genome sequences from Atlantic, Mediterranean, and Black Sea populations. By also analysing linked-read sequencing data, we found evidence for two chromosomal inversions that were several megabases in length and showed contrasting allele frequency patterns between lineages and ecotypes across the species range. We reveal that these inversions represent ancient intraspecific polymorphisms, one likely being maintained by divergent selection and the other by pseudo-overdominance. A possible selective coupling between the two inversions was further supported by the absence of specific haplotype combinations and a putative functional interaction between the two inversions in reproduction. Lastly, we detected gene flux eroding divergence between inverted alleles at varying levels for the two inversions, with a likely impact on their dynamics and contribution to divergence and speciation.pt_PT
dc.description.sponsorshipCoGeDivANR-17-CE02-0006-01pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1111/mec.17277pt_PT
dc.identifier.issn0962-1083
dc.identifier.urihttp://hdl.handle.net/10400.1/20411
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAncestral recombination graphpt_PT
dc.subjectEcotypespt_PT
dc.subjectEvolutionary historypt_PT
dc.subjectGene fluxpt_PT
dc.subjectInversionspt_PT
dc.subjectWhole-genome resequencingpt_PT
dc.titleDivergence and gene flow history at two large chromosomal inversions underlying ecotype differentiation in the longā€snouted seahorsept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage17277pt_PT
oaire.citation.titleMolecular Ecologypt_PT
person.familyNameLopes da Cunha
person.givenNameRegina
person.identifier.orcid0000-0002-4275-9723
person.identifier.ridM-3463-2013
person.identifier.scopus-author-id8855869800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0ff4c823-415a-4f2c-99ed-f849419fd307
relation.isAuthorOfPublication.latestForDiscovery0ff4c823-415a-4f2c-99ed-f849419fd307

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