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The role of decavanadate in anti-tumor activity
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Orientador(es)
Resumo(s)
Decavanadate compounds were described to be involved in a variety of biological activities and
responses such as anti-virus, anti-bacterial and anticancer. While the mechanisms of action of the antiviral
and anti-bacterial activities are better understood, the same does not go for the anti-tumour activity.
Nevertheless, the inhibition of tumour proliferation seems to impact certain enzymes such as alkaline
phosphatase, ecto-nucleotidases or P-type ATPases. In the present report, several studies are described,
in a way to explain the increasing interest of these polyoxometalate in cancer therapy. The detailed
knowledge of the molecular basis of decavanadate–proteins and cellular interactions allows to better
understand the processes associated with the anticancer applications, not only for decavanadate but as
well for other polyoxometalates (POMs).
Descrição
Palavras-chave
Decavanadate Anticancer Polyoxometalates (Poms)
Contexto Educativo
Citação
Editora
Peertechz Publications Pvt. Ltd.