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Hypoxia impairs survival and alters immune and iron metabolism gene expression during shark early ontogeny

2025-10Artigo científico Acesso aberto
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datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorMartins, Sandra
dc.contributor.authorVarela, Jaquelino
dc.contributor.authorFélix, Rute
dc.contributor.authorSantos, Catarina Pereira
dc.contributor.authorPaula, José Ricardo
dc.contributor.authorPower, Deborah Mary
dc.contributor.authorRosa, Rui
dc.date.accessioned2026-03-19T10:47:16Z
dc.date.available2026-03-19T10:47:16Z
dc.date.issued2025-10
dc.description.abstractThe global oxygen inventory has been declining worldwide, primarily due to climate change. The importance of oxygen for aerobic respiration and its homeostasis makes declining oxygen levels a concern, particularly during energy demanding lifecycle stages. The effects of low oxygen levels on neuroendocrine responses and immune competence of developing sharks were studied in the head and trunk tissues of early (EE; before pre-hatching) and late embryos (LE) of small-spotted catshark (Scyliorhinus canicula) under six days of deoxygenation (93 % O2 of air saturation) and hypoxic conditions (26 % O2). Catshark embryos were resilient to deoxygenation, with only a 10 % decline in survival compared to the control, and only the gene expression of melanotransferrin changed. Under hypoxia, growth was unaffected, but survival decreased by 31 % compared to the control in LE, highlighting an inadequate physiological response. Developmental stage affected the expression of hypoxiainducible factor 1 alpha (hif1a), iron metabolism and immune-related genes, pointing to critical response mechanisms. The EE stage had an optimised stress response under hypoxia compared to LE, with the upregulation of the hif1a gene. The lack of a protective response and compromised immune-related functions under hypoxia in LE raise concerns about species survival under climate change. These findings highlight the need for further research on the likely resilience of sharks to environmental challenges.eng
dc.description.sponsorshipCOVID/BD/153548/2024; 142382; UID/MAR/04292/2020; 100010434; 100.54499/UIDP/04326/2020
dc.identifier.doi10.1016/j.cbpa.2025.111904
dc.identifier.eissn1531-4332
dc.identifier.issn1095-6433
dc.identifier.urihttp://hdl.handle.net/10400.1/28479
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAquatic Research Infrastructure Network
dc.relationMultigenerational adaptation of ascidians to ocean warming and acidification
dc.relationalterado para: “Immune and neuroendocrine responses of sharks to anthropogenic pressures” Immune and neuroendocrine response to climate change of teleost and cartilaginous fish
dc.relationalterado para: “Sharks in a changing ocean: a multiscale assessment of anthropogenic pressures on key marine predators”, Sharks Sixth Sense in a Changing Ocean - Effects of Ocean Warming and Acidification on Sharks Electroreception Sixth Sense in a Changing Ocean - Effects of Ocean Warming and Acidification on Sharks Electroreception
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relation.ispartofComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDeoxygenation
dc.subjectEmbryos
dc.subjectEndocrinology
dc.subjectHypoxia
dc.subjectImmunology
dc.subjectScyliorhinus canicular
dc.subjectSharks
dc.titleHypoxia impairs survival and alters immune and iron metabolism gene expression during shark early ontogenyeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberLA/P/0069/2020
oaire.awardNumberPTDC/BIA-BMA/28609/2017
oaire.awardNumberSFRH/BD/145276/2019
oaire.awardNumberSFRH/BD/117890/2016
oaire.awardNumberUIDB/04326/2020
oaire.awardNumberUIDP/04326/2020
oaire.awardNumberLA/P/0101/2020
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardTitleMultigenerational adaptation of ascidians to ocean warming and acidification
oaire.awardTitlealterado para: “Immune and neuroendocrine responses of sharks to anthropogenic pressures” Immune and neuroendocrine response to climate change of teleost and cartilaginous fish
oaire.awardTitlealterado para: “Sharks in a changing ocean: a multiscale assessment of anthropogenic pressures on key marine predators”, Sharks Sixth Sense in a Changing Ocean - Effects of Ocean Warming and Acidification on Sharks Electroreception Sixth Sense in a Changing Ocean - Effects of Ocean Warming and Acidification on Sharks Electroreception
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0069%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F145276%2F2019/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.startPage111904
oaire.citation.titleComparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
oaire.citation.volume308
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
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oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMartins
person.familyNameFélix
person.familyNamePower
person.givenNameSandra
person.givenNameRute
person.givenNameDeborah Mary
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person.identifier.orcid0000-0002-3720-2920
person.identifier.orcid0000-0002-4144-3452
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-6164-2013
person.identifier.scopus-author-id56006773000
person.identifier.scopus-author-id7101806760
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