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HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington's Disease

2017-07Journal article Open access
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dc.contributor.authorReddy Kalathur, Ravi Kiran
dc.contributor.authorPinto, Jose Pedro
dc.contributor.authorSahoo, Biswanath
dc.contributor.authorChaurasia, Gautam
dc.contributor.authorFutschik, Matthias E.
dc.date.accessioned2018-12-07T14:53:15Z
dc.date.available2018-12-07T14:53:15Z
dc.date.issued2017-07
dc.description.abstractHuntington's disease (HD) is a progressive and fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although HD is monogenic, its molecular manifestation appears highly complex and involves multiple cellular processes. The recent application of high throughput platforms such as microarrays and mass-spectrometry has indicated multiple pathogenic routes. The massive data generated by these techniques together with the complexity of the pathogenesis, however, pose considerable challenges to researchers. Network-based methods can provide valuable tools to consolidate newly generated data with existing knowledge, and to decipher the interwoven molecular mechanisms underlying HD. To facilitate research on HD in a network-oriented manner, we have developed HDNetDB, a database that integrates molecular interactions with many HD-relevant datasets. It allows users to obtain, visualize and prioritize molecular interaction networks using HD-relevant gene expression, phenotypic and other types of data obtained from human samples or model organisms. We illustrated several HDNetDB functionalities through a case study and identified proteins that constitute potential cross-talk between HD and the unfolded protein response (UPR). HDNetDB is publicly accessible at http://hdnetdb.sysbiolab.eu.
dc.description.sponsorshipCHDI Foundation [A-2666]; Portuguese Fundacao para a Ciencia e a Tecnologia [SFRH/BPD/70718/2010, SFRH/BPD/96890/2013, IF/00881/2013, UID/BIM/04773/2013 - CBMR, UID/Multi/04326/2013 - CCMAR]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1038/s41598-017-05224-0
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/11429
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Publishing Group
dc.relationSYSTEMS BIOLOGY APPROACH TO UNRAVEL THE MOLECULAR MECHANISMS INVOLVED IN T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA
dc.relationDEVELOPMENT OF SOFTWARE TOOLS FOR THE PREDICTION OF CELULAR FATE IN STEM CELL DIFERENTIATION
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectProtein-interaction network
dc.subjectAge-Of-Onset
dc.subjectC-Jun
dc.subjectMutant huntingtin
dc.subjectGene-expression
dc.subjectNeurodegenerative disease
dc.subjectTherapeutic target
dc.subjectModel organisms
dc.subjectSpiny neurons
dc.subjectEr stress
dc.titleHDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington's Disease
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSYSTEMS BIOLOGY APPROACH TO UNRAVEL THE MOLECULAR MECHANISMS INVOLVED IN T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA
oaire.awardTitleDEVELOPMENT OF SOFTWARE TOOLS FOR THE PREDICTION OF CELULAR FATE IN STEM CELL DIFERENTIATION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F70718%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F96890%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.citation.startPage5216
oaire.citation.titleScientific Reports
oaire.citation.volume7
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameFutschik
person.givenNameMatthias
person.identifier.ciencia-idA71B-AD01-3501
person.identifier.orcid0000-0002-6245-8071
person.identifier.scopus-author-id14017989400
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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