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Six Algerian plants: Phenolic profile, antioxidant, antimicrobial activities associated with different simulated gastrointestinal digestion phases and antiproliferative properties

2023-03Journal article Restricted access
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dc.contributor.authorEr Kemal, Mehtap
dc.contributor.authorBakchiche, Boulanouar
dc.contributor.authorKemal, Mehmet
dc.contributor.authorCheraif, Kadour
dc.contributor.authorKara, Yakup
dc.contributor.authorBardaweel, Sanaa K.
dc.contributor.authorMiguel, Maria
dc.contributor.authorYildiz, Oktay
dc.contributor.authorGhareeb, Mosad A.
dc.date.accessioned2023-03-28T10:23:06Z
dc.date.available2023-03-28T10:23:06Z
dc.date.issued2023-03
dc.description.abstractIntroduction: Mediterranean countries, including Algeria, have medicinal plants used in folk medicine, such as Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L., and Lavandula angustifolia Mill. It is noteworthy that the bioaccessibility of their polyphenolic ingredients have not been critically evaluated before. Methods: The bioactive properties of the aqueous extracts of Artemisia campestris L., Artemisia herba-alba Asso, Juniperus phoenicea L., Juniperus oxycedrus L., Mentha pulegium L., and Lavandula angustifolia Mill. were investi-gated. They were subjected to a simulated gastrointestinal digestion to evaluate the antioxidant, antimicrobial activities and total polyphenol contents. Their antiproliferative activities against three human cancer cell lines (MCF-7, T47D, and Caco-2) were also performed using the aqueous extracts. The phenolic profile was also studied by reversed-phase high-performance liquid chromatography coupled to ultraviolet spectrometry detector (RP-HPLC-UV). Results: The results indicated that bioaccessibility of total phenolic compounds after the post-gastric, intestinal, and colon phases was in the ranges of 4.34-11.57 %, 0-0.55 %, and 3.92-9.24 %, respectively when compared with their aqueous extracts. Intestinal and colon phase samples collected from intestinal digestion of six plant extracts did not have any antioxidant activity. Juniperus spp. extracts had the highest antiproliferative activity compared to the results obtained from other tested species. Conclusions: The high antioxidant and cytotoxic activities of Juniperus samples may be attributed to the higher levels of total phenols, as well as the catechins, rutin and caffeic acid, whilst M. pulegium extract with the lowest phenolic content and lower amounts of these metabolites, having p-coumaric acid as a predominant phenolic compound, was shown to be less effective as an antioxidant and anticancer agent.pt_PT
dc.description.sponsorshipAlgerian Ministry of Higher Education and Scientific Research A16N01UN030120230001?pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.hermed.2023.100636pt_PT
dc.identifier.eissn2210-8041
dc.identifier.urihttp://hdl.handle.net/10400.1/19327
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMediterranean Institute for Agriculture, Environment and Development
dc.subjectAlgerian plantspt_PT
dc.subjectBioaccessibilitypt_PT
dc.subjectBioactivityIn vitro digestionpt_PT
dc.subjectArtemisiapt_PT
dc.subjectJuniperuspt_PT
dc.subjectMenthapt_PT
dc.subjectLavandulapt_PT
dc.titleSix Algerian plants: Phenolic profile, antioxidant, antimicrobial activities associated with different simulated gastrointestinal digestion phases and antiproliferative propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMediterranean Institute for Agriculture, Environment and Development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05183%2F2020/PT
oaire.citation.startPage100636pt_PT
oaire.citation.titleJournal of Herbal Medicinept_PT
oaire.citation.volume38pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMiguel
person.givenNameMaria da Graça
person.identifier.ciencia-id6110-6FE7-DF28
person.identifier.orcid0000-0003-2507-4228
person.identifier.scopus-author-id35562054500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2507350f-9e60-4d4a-a096-53e58d93549c
relation.isAuthorOfPublication.latestForDiscovery2507350f-9e60-4d4a-a096-53e58d93549c
relation.isProjectOfPublication823bd652-ee6c-4479-91c5-06095bc37e9c
relation.isProjectOfPublication.latestForDiscovery823bd652-ee6c-4479-91c5-06095bc37e9c

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