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Skin and scale regeneration after mechanical damage in a teleost

dc.contributor.authorCosta, Rita
dc.contributor.authorPower, Deborah
dc.date.accessioned2020-07-30T11:02:24Z
dc.date.available2020-07-30T11:02:24Z
dc.date.issued2018-03
dc.description.abstractSkin wound healing has been widely studied in mammalian models but the information on teleost cutaneous healing is sparse and frequently considered in the context of viral or bacterial infections or parasitic infestations in aquaculture. In the present study a detailed time course (0 h, 6 h, 1, 2, 3 and 4 days) coupled to morphology and gene expression analysis revealed rapid regeneration of skin without scarring in a marine teleost after a superficial wound caused by the loss of a large area of scales. The integrity of the integument, as assessed by quantification of extracellular matrix (ECM) gene transcripts (fn1a, colIα1, colVα2, colXα1, ogn1, ogn2, crtac1a, cyr61, pcna, krt2 and mmp9) was restored within 2 days. Epithelial-mesenchyme interactions assessed by expression of edar and shh were associated with epidermal closure, the re-establishment of the basement membrane and also scale eruption. Histological observations suggested tissue re-epithelialization was independent of inflammation and that transcripts representing the humoral and cellular elements of the immune response (mpo, cyba and csf1r, cd48 and cd200) were modulated in the early stages of sea bream (Sparus aurata) skin repair after injury. Overall, the results indicate that after superficial skin damage tissue reconstitution started immediately with re-epithelialization, followed by ECM deposition and finally tissue maturation, indicating that in the skin regenerative process, reconstitution of the physical barrier was the priority over other integument functions, including immune surveillance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.molimm.2018.01.016pt_PT
dc.identifier.issn0161-5890
dc.identifier.urihttp://hdl.handle.net/10400.1/14552
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAnimal Scalespt_PT
dc.subjectAnimalspt_PT
dc.subjectGene Expression Regulationpt_PT
dc.subjectRegenerationpt_PT
dc.subjectSea Breampt_PT
dc.subjectSkinpt_PT
dc.subjectWound Healingpt_PT
dc.subjectSkin Physiological Phenomenapt_PT
dc.subjectRegenerationpt_PT
dc.subjectTeleostpt_PT
dc.titleSkin and scale regeneration after mechanical damage in a teleostpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F81625%2F2011/PT
oaire.citation.endPage82pt_PT
oaire.citation.startPage73pt_PT
oaire.citation.titleMolecular Immunologypt_PT
oaire.citation.volume95pt_PT
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameCosta
person.familyNamePower
person.givenNameRita
person.givenNameDeborah Mary
person.identifier.ciencia-id8219-DFF3-929F
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-6975-7576
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridO-9136-2018
person.identifier.scopus-author-id57097731700
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscovery943d1248-7839-42b3-89a9-b539b3209cd7
relation.isProjectOfPublication868b4818-3efa-4edb-9202-c464d64fd38f
relation.isProjectOfPublicationc608770e-9df0-44d1-9817-41c79b51b809
relation.isProjectOfPublication.latestForDiscovery868b4818-3efa-4edb-9202-c464d64fd38f

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